894787-92-9

Upstream product

• 894787-96-3 5-bromo-2-hydroxy-4-(4-fluorophenyl)-6-isopropylpyrimidine 
• 1184-85-6 N-methylmethane sulphonamide 
• 894787-97-4 5-bromo-2-chloro-4-(4-fluorophenyl)-6-isopropylpyrimidine 

Downstream Products

• 901765-35-3 trans-N-(5-(2-cyanovinyl)-4-(4-fluorophenyl)-6-isopropyl-2-pyrimidinyl)-N-methylmethanesulfonamide 
• 289042-12-2 2-[(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(isopropyl)pyrimidin-5-yl]vinyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert butyl ester 
• 910867-08-2 (E)-N-(4-(4-fluorophenyl)-5-(3-hydroxyprop-1-en-1-yl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide 

Relevant academic research and scientific papers

Chemical Process

A process for formation of a compound of formula (I) or a pharmaceutically acceptable salt thereof, (A chemical formula should be inserted here—please see paper copy enclosed herewith) I via a Heck reaction is described. Intermediates useful in the process and processes for making said intermediates are also described.

PROCESS FOR THE PREPARATION OF ROSUVASTATIN

A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described.

PROCESSES FOR THE MANUFACTURE OF ROSUVASTATIN AND INTERMEDIATES

A process for the manufacture of a compound of formula (V), useful for making rosuvastatin, by a stereoselective aldol reaction is described. Novel intermediates and processes to make them are also described.