894795-05-2Relevant academic research and scientific papers
BICYCLIC PYRROLE DERIVATIVES
-
, (2008/06/13)
Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.]
BICYCLIC PYRROLE DERIVATIVES
-
Page/Page column 151-152, (2008/06/13)
Compounds represented by the general formula (Ι), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (Ι) wherein the solid or broken line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen or the like; R1 is hydrogen, optionally substituted alkyl, or the like; R2 is hydrogen, optionally substituted alkyl, or the like; R3 is hydrogen, halogeno, or the like; R4 is hydrogen, hydroxyl, halogeno, or the like; and Y is a group represented by the general formula (A) or the like: (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogeno or the like].
