89485-50-7

Upstream product

• 55221-50-6 cis-bis(benzylamine)dichloroplatinum(II) 
• 25478-67-5 tetraethylammonium tetrachloroaurate(III) 
• 55221-50-6 trans-bis(benzylamine)dichloroplatinum(II) 
• 100-46-9 benzylamine 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship of benzylamine supported platinum(iv) complexes

A series of benzylamine derivative (BAD) supported platinum(iv) complexes (PtCl4(BADs)2) have been synthesized. The complexes were tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities. Their DNA binding nature for a structure-activity relationship (SAR) study was investigated with physicochemical-indicators (PCI) which categorized them as good intercalators for host-guest chemistry. A mechanism for drug efficacy is proposed by analysis of the resultant viscosity and surface tension of PtCl 4(BADs)2-DNA solutions named as the drug-friccohesity interaction (DFI). The complexes have shown significant antioxidant activity, determined on the basis of free radical scavenging effects due to their terminating action against the reactive species.

Effects of Geometric Configuration and Steric Hindrance on Rates and Mechanisms of Oxidation of Diaminedichloroplatinum(II) Complexes by Tetrachloroaurate(III) Ions

The oxidation reactions of trans- and/or cis- by - in the presence of Cl have been kinetically investigated in acetonitrile (R=H,Me,Et,Prn,Pri,Bun,Bui,Bus,But,CH2But,CH2Ph, or cyclo-C6H11).The rate law for the oxidation of the trans complexes consists mainly of a third-order rate term, kc->->, whereas an additiona rate term, ka->->/(1+kb->), operates in the case of the cis complexes.A reaction scheme is proposed.The oxidation rates of both cis and trans complexes appear to be reduced by increasing the steric hindrance of the amine, cis complexes being more sensitive towards changes of steric hindrance than trans analogues.Approximate linear relationships correlate the reactivities (log k) of both cis and trans complexes with an amine steric hindrance parameter.