894853-81-7

Basic information

• Product Name: (2-{(1S,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-[1-methanesulfonyl-meth-(E)-ylidene]-cyclohexylmethoxy}-ethyl)-trimethyl-silane
• Synonyms: (2-{(1S,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-[1-methanesulfonyl-meth-(E)-ylidene]-cyclohexylmethoxy}-ethyl)-trimethyl-silane
• CAS NO: 894853-81-7
• Molecular Weight: 591.212
• Mol File: 894853-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-{(1S,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-[1-methanesulfonyl-meth-(E)-ylidene]-cyclohexylmethoxy}-ethyl)-trimethyl-silane(CAS DataBase Reference)
• NIST Chemistry Reference: (2-{(1S,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-[1-methanesulfonyl-meth-(E)-ylidene]-cyclohexylmethoxy}-ethyl)-trimethyl-silane(894853-81-7)
• EPA Substance Registry System: (2-{(1S,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-[1-methanesulfonyl-meth-(E)-ylidene]-cyclohexylmethoxy}-ethyl)-trimethyl-silane(894853-81-7)

Safety Data

• Hazardous Substances Data: 894853-81-7(Hazardous Substances Data)

Upstream product

• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 894853-74-8 (2R,4S)-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-2-[2-(trimethylsilyl)ethoxymethyl]cyclohexanone 
• 40137-11-9 diethyl methylsulfonylmethylphosphonate 
• 471903-20-5 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone 

Downstream Products

• 894853-84-0 Toluene-4-sulfonic acid (1S,2R,5S)-5-(4-chloro-benzenesulfonyl)-2-(diethoxy-phosphorylmethanesulfonylmethyl)-5-(2,5-difluoro-phenyl)-cyclohexylmethyl ester 
• 894853-83-9 [(1R,2S,4S)-4-(4-Chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-(2-trimethylsilanyl-ethoxymethyl)-cyclohexylmethanesulfonylmethyl]-phosphonic acid diethyl ester 
• 894853-88-4 [(1R,2S,4S)-4-(4-Chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-2-hydroxymethyl-cyclohexylmethanesulfonylmethyl]-phosphonic acid diethyl ester 
• 894853-85-1 [(4aR,6S,8aR)-6-(4-Chloro-benzenesulfonyl)-6-(2,5-difluoro-phenyl)-2,2-dioxo-decahydro-2λ⁶-isothiochromen-3-yl]-phosphonic acid diethyl ester 
• 894853-86-2 (4aS,6S,8aR)-6-(4-Chloro-benzenesulfonyl)-6-(2,5-difluoro-phenyl)-3-eth-(E)-ylidene-octahydro-isothiochromene 2,2-dioxide 
• 894853-82-8 {2-[(1S,2R,5S)-5-(4-Chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-methanesulfonylmethyl-cyclohexylmethoxy]-ethyl}-trimethyl-silane 

Relevant articles and documents

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The 3,4-fused sulfamides, sulfonamides and sulfone have been identified as highly potent γ-secretase inhibitors. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce br