89488-96-0

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as a building block for the synthesis of pharmaceuticals due to its versatile chemical properties and potential biological activities.
Used in Agrochemical Industry:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as a building block for the synthesis of agrochemicals, contributing to the development of effective products for agricultural applications.
Used as a Reagent in Organic Synthesis:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as a reagent in organic synthesis, facilitating various chemical reactions and the formation of new compounds.
Used as a Pharmaceutical Intermediate:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as a pharmaceutical intermediate in the production of various drugs, playing a crucial role in the development of new medications.
Used in Antifungal Applications:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as an antifungal agent, leveraging its biological activity to combat fungal infections.
Used in Antibacterial Applications:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as an antibacterial agent, utilizing its biological properties to fight against bacterial infections.
Used in Antitumor Applications:
Ethyl (2-methyl-2H-tetrazol-5-yl)acetate is used as an antitumor agent, harnessing its potential to inhibit tumor growth and contribute to cancer treatment.

Upstream product

• 13616-37-0 ethyl (tetrazol-5-yl)acetate 
• 74-88-4 methyl iodide 
• 13616-37-0 ethyl 2-(2H-1,2,3,4-tetraazol-5-yl)acetate 

Downstream Products

• 21743-77-1 (2-methyl-2H-tetrazol-5-yl)-acetic acid 

Relevant academic research and scientific papers

Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p Kaand LogD Modulation

Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modulation and perception, and TRPM8 antagonists have been proposed as potential therapeutic approaches for pain treatment. Previously, we developed two TRPM8 antagonists and proposed them as drug candidates for topical and systemic pain treatment. Here, we describe the design and synthesis of these two TRPM8 antagonists (27 and 45) and the rational approach of modulation/replacement of bioisosteric chemical groups, which allowed us to identify a combination of narrow ranges of pKa and LogD values that were crucial to ultimately optimize their potency and metabolic stability. Following the same approach, we then pursued the development of new TRPM8 antagonists suitable for the topical treatment of ocular painful conditions and identified two new compounds (51 and 59), N-alkoxy amide derivatives, that can permeate across ocular tissue and reduce the behavioral responses induced by the topical ocular menthol challenge in vivo.

Water-Soluble Platinum(II) Complexes Featuring 2-Alkyl-2H-tetrazol-5-ylacetic Acids: Synthesis, Characterization, and Antiproliferative Activity

2-R-2H-Tetrazol-5-ylacetic acids (abbreviated as 2-R-taa; R = Me, iPr, tBu) react with K2[PtCl4] in 1 m HCl in H2O at r.t. furnishing trans-platinum(II) complexes trans-[PtCl2(2-R-taa)2] (1–3), whereas cis-isomeric species cis-[PtCl2(2-R-taa)2] (R = iPr, 4; tBu, 5) are isolated at lower temperature (4–6 °C). In the presence of EtOH in the reaction mixture, esterification of the tetrazol-5-ylacetoxy group of 2-tBu-taa leads to trans-[PtCl2(ethyl 2-tert-butyl-2H-tetrazol-5-ylacetate)2] (6). Complexes 1–6 were characterized by elemental analyses (CHN), HRESI+-MS,1H,13C{1H},195Pt{1H} NMR and IR spectroscopy, differential scanning calorimetry/thermogravimetry (DSC/TG), and X-ray diffraction (for 1·H2O, 2, 3·2H2O, 4, 5·2H2O, and 6). The generation of the tetrazole-based complexes in solution (1 m DCl in D2O, 25 °C) was studied by1H NMR spectroscopy and HPLC-MS. The obtained data indicate the initial formation of anionic [PtCl3(2-R-taa)]–complexes that are subsequently converted into disubstituted isomeric platinum(II) species cis- and trans-[PtCl2(2-R-taa)2]. By contrast to cis- and trans-[PtCl2(2-R-taa)2] that were inactive in two human cancer models in vitro (IC50> 100 μm), complex 6 demonstrated noticeable antiproliferative effects in HT-29 colon and MCF-7 breast carcinoma cell lines with IC50values of 14.2 ± 1.1 and 5.8 ± 1.2 μm, respectively.

Substituted enaminones, their derivatives and uses thereof

The present invention is related substituted enaminones represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine a

A reagent, ethyl 2-(2-tert-butyl-2H-tetrazol-5-yl)-3-(dimethylamino)acrylate (DMTE), for facile synthesis of 2,3-(ring fused)-5-(5-tetrazolyl)-4H-pyrimidin-4-one derivatives

A method for synthesizing 2,3-(ring fused)-5-(5-tetrazolyl)-4H-pyrimidin-4-one derivatives from ethyl 2-(2-tert-butyl-2H-tetrazol-5-yl)-3-(dimethylamino)acrylate (DMTE) (4a) and amino-heterocycles is described. The structure of DMTE, which was prepared from ethyl (2-tert-butyl-2H-tetrazol-5-yl)acetate (3a) with dimethylformamide diethylacetal, was determined by X-ray analysis to be Z form. The reaction of 2-amino-5-methyloxazole (6) with DMTE in acetic acid gave the oxazolo[3,2-a]pyrimidine derivative (8), heating of which in concentrated sulfuric acid afforded the desired tetrazole derivative (20). Pyrimido[2,1-b]benzothiazole (21), pyrazolo[1,5-a]pyrimidine (22 and 23) and [1,2,4]triazolo[1,5-a]pyrimidine (24) derivatives were prepared in a similar manner.