89499-46-7Relevant academic research and scientific papers
REDUCTIVE ACYLATION OF 5-NITRO-2R-THIOPHENES
Glushkova, A. A.,Morgunova, L. M.,Freidlin, G. N.,Fedorov, A. Ya.,Ivanov, V. F.
, p. 380 - 384 (2007/10/02)
A study was made of the kinetics of the reduction of eleven 5-nitro-2-substituted thiophenes to acetylaminothiophenes using Raney nickel in acetic anhydride.The dependence of the rate of the reaction both on the induction effect of the substituents and on the ratio of the adsorption constants of the reaction products and substrate was determined.
REDUCTIVE ACETYLATION OF NITROCARBOXYLIC ACIDS OF THE THIOPHENE AND FURAN SERIES OR THEIR ESTERS
Gol'dfarb, Ya. L.,Bulgakova, V. N.,Fabrichnyi, B. P.
, p. 1283 - 1286 (2007/10/02)
The corresponding 4-acetylamino-2-thiophenecarboxylic acids or their esters were produced by the action of reduced iron on solutions of 4-nitro-2-thiophenecarboxylic acid, its derivatives, or their esters in a mixture of acetic acid and acetic anhydride.Esters of 5-acetylamino-2-thiophenecarboxylic or 5-acetylamino-2-furancarboxylic acids are formed from esters of 5-nitro-2-thiophenecarboxylic or 5-nitro-2-furancarboxylic acids.Free 5-nitro-2-thiophenecarboxylic and 5-nitro-2-furancarboxylic acids are entirely decomposed under the conditions of reductive acetylation by iron.The ester of 5-acetylamino-3-thiphenecarboxylic acid was obtained from methyl ester of 5-nitro-3-thiophenecarboxylic acid.
