895-32-9

Upstream product

• 98-01-1 furfural 
• 502-42-1 cycloheptanone 

Relevant academic research and scientific papers

Synthesis, molecular modeling and bio-evaluation of cycloalkyl fused 2-aminopyrimidines as antitubercular and antidiabetic agents

An economical and efficient one step synthesis of a series of 8-(arylidene)-4-(aryl)-5,6,7,8-tetrahydro-quinazolin-2-ylamines and 9-(arylidene)-4-(aryl)-6,7,8,9-tetrahydro-5H-cycloheptapyrimidin-2-ylamines by the reaction of bis-benzylidene cycloalkanones and guanidine hydrochloride in presence of NaH has been developed. All the synthesized compounds were evaluated against Mycobacterium tuberculosis H37Rv strain and the α-glucosidase and glycogen phosphorylase enzymes. Few of the compounds have shown interesting in vitro activity with MIC up to 3.12 μg/mL against M. tuberculosis and very good inhibition of α-glucosidase and glycogen phosphorylase enzymes. The most potent non toxic compound 40 exhibited about 58% ex vivo activity at MIC of 3.12 μg/mL. The present study opens a new gate to synthesize antitubercular agents for diabetic TB patients. In silico docking studies indicate that mycobacterial dihydrofolate reductase is the possible target of these compounds.

Ultrasound promoted synthesis of α,α'-bis(substituted furfurylidene) cycloalkanones and chalcones

Condensation of furfural with cycloalkanones and substituted acetophenones catalysed by potassium hydroxide results α,α'- bis(substituted furfurylidene) cycloalkanones and chalcones in high yield under ultrasound irradiation in 4-50 min.

Convenient synthesis of α,α1-bis (substituted furfurylidene) cycloalkanones and chalcones under microwave irradiation

Condensation of furfural with cycloalkanones and substituted acetophenones catalyzed by solid NaOH results in α,α1-bis (substituted furfurylidene) cycloalkanones and chalcones in high yield under microwave irradiation for a duration of 2 minute