89507-41-5Relevant academic research and scientific papers
Synthesis of deuterium-labeled fluphenazine
Shetty,Hawes,Midha
, p. 87 - 90 (2007/10/02)
The propylpiperazine side chain of fluphenazine has been labeled with two, four, and six deuterium atoms by lithium aluminum deuteride reduction of the appropriate ester or imide. The γ-carbon of the propyl group was labeled with two deuterium atoms by reduction of 10- (2-methoxycarbonylethyl)-2-trifluoromethyl-10H-phenothiazine, while four deuterium atoms were incorporated into the piperazine ring by reduction of 10-[3-(3,5-dioxo-1-piperazinyl)propyl]-2-trifluoro-methyl-10H-phenothiazin e. The latter reduction gave the d4-labeled N-deshydroxyethyl metabolite of fluphenazine.
