89507-60-8

Usage

Molecular Weight

208.25 g/mol

Physical State

Colorless liquid

Uses

Reagent in organic synthesis, reactive diluent in epoxy resins, cross-linking agent in polymer chemistry, building block for pharmaceuticals and agrochemicals

Hazards

May cause skin and eye irritation, harmful if swallowed or inhaled.

Upstream product

• 1260168-27-1 2-(2-methoxyethenyl)phenol 
• 90-02-8 salicylaldehyde 
• 330976-39-1 2-hydroxyphenethyl methyl ether 
• 106-89-8 epichlorohydrin 

Relevant academic research and scientific papers

Synthesis method of metroprolol succinate ortho-isomer impurities

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a synthesis method of metroprolol succinate ortho-isomer impurities. The synthesis method comprises thesteps: the metroprolol succinate ortho-isomer impurities are prepared by taking salicylaldehyde as a raw material through four steps of reactions, namely the Wittig reaction, the reduction hydrogenation reaction, the substitution reaction and the ring-opening reaction. The synthesis method of the metroprolol succinate ortho-isomer impurities totally includes the four steps of reactions, the raw material is easy to obtain, the total yield is greater than 40%, and contribution is made to strictly control the content of the metroprolol succinate ortho-isomer impurities through an external standard method; and the synthesis method of the metroprolol succinate ortho-isomer impurities is easy to operate, mild in reaction, high in product purity and suitable for drug quality study.