89508-48-5

Basic information

• Product Name: 4,6-DICHLORO-2-(4-PYRIDINYL)PYRIMIDINE
• Synonyms: 4,6-DICHLORO-2-(4-PYRIDINYL)PYRIMIDINE
• CAS NO: 89508-48-5
• Molecular Formula: C₉H₅Cl₂N₃
• Molecular Weight: 226.06
• Mol File: 89508-48-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,6-DICHLORO-2-(4-PYRIDINYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-(4-PYRIDINYL)PYRIMIDINE(89508-48-5)
• EPA Substance Registry System: 4,6-DICHLORO-2-(4-PYRIDINYL)PYRIMIDINE(89508-48-5)

Safety Data

• Hazardous Substances Data: 89508-48-5(Hazardous Substances Data)

Upstream product

• 1193-21-1 4,6-dichloropyrimidine 
• 1120-87-2 4-bromopyridin 
• 204394-76-3 2-(pyridin-4-yl)pyrimidine-4,6-diol 
• 6345-27-3 4-amidinopyridine hydrochloride 

Relevant articles and documents

Nitrogen heterocyclic compound, display panel and display device

The invention belongs to the technical field of OLEDs and provides a nitrogen heterocyclic compound. The structure of the nitrogen heterocyclic compound is shown as a chemical formula 1; wherein X1 and X2 each independently represent C or N, and at least one of X1 and X2 is an N atom; X3 to X7 each independently represent N or -CRa, and 1 to 4 of X3 to X7 are N atoms; Ra is selected from hydrogen,deuterium, a Cl-C20 alkyl group, a Cl-C20 alkoxy group, a Cl-C20 thioalkyl group, a C6-C30 aryl group, or a C3-C30 heteroaryl group; Ra independently exists or forms an aliphatic ring, an aromatic ring or a heteroaromatic ring with an adjacent carbon atom; Ar1 and Ar2 are each independently selected from the group consisting of a C6-C30 aryl group and a C3-C30 heteroaryl group; L1 and L2 are independently a single bond, a C6-C30 arylene group, or a C3-C30 heteroarylene group. When the nitrogen heterocyclic compound provided by the invention is used as a cap layer material of an OLED, a relatively high refractive index can be obtained, the external quantum efficiency of an organic light-emitting device can be effectively improved, and the nitrogen heterocyclic compound has a very small extinction coefficient in a blue light region (400-450 nm), hardly absorbs blue light, and is beneficial to improving the light-emitting efficiency. The invention further provides a display panel and a display device.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

In this paper we describe the optimization of a phenotypic hit against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold. This led to compounds with good pharmacokinetics and oral activity in a P. berghei mouse model of malaria. The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P. berghei mouse model of malaria. It also demonstrated a rapid rate of clearance of the erythrocytic stage of P. falciparum in the SCID mouse model with an ED90 of 11.7 mg/kg when dosed orally. Unfortunately, the compound is a potent inhibitor of cytochrome P450 enzymes, probably due to a 4-pyridyl substituent. Nevertheless, this is a lead molecule with a potentially useful antimalarial profile, which could either be further optimized or be used for target hunting.

Pyrimidine derivatives as IL-8 receptor antagonists

Compounds containing the pyrimidine nucleus and their use to treat diseases and conditions related to inappropriate Interleukin-8 receptor activity are disclosed. The compounds are of the formula I In these compounds, Q is preferably unsubstituted and substituted heterocyclyl; U is usually hydrogen or fluorine; and V is preferably hydrogen, halogen, alkyl, —O—alkyl or —S-alkyl. A representative example is: