89515-07-1Relevant academic research and scientific papers
NOVEL 3-METHYL-7-BUTINYL-XANTHINES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS
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Page/Page column 31, (2008/06/13)
The invention relates to novel substituted xanthines of general formula (I), wherein R1, R2, and X are defined as mentioned in the claims, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof, which have valuable pharmaceutical properties, especially an inhibitive effect on the activity of the dipeptidyl peptidase-IV (DPP-IV) enzyme.
Studies on agents with vasodilator and β-blocking activities. II
Seki,Takezaki,Ohuchi,Ohuyabu,Tanimoto,Yamaguchi,Saitoh,Ishimori,Yasuda
, p. 247 - 255 (2007/10/02)
A series of phenoxypropanolamines having a hydrazinopyridazinyl moiety was synthesized. Their hypotensive and β-blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Some of them exhibited both activities. In particular, compound 20k is a candidate for clinical use due to its hypotensive activity, equal to that of hydralazine, and its β-blocking activity, 2.7-fold more potent than that of propranolol.
Agents for the treatment of overactive detrusor. VIII. Synthesis and pharmacological properties of 4,4-diphenyl-2-cycloalkenylamines including FK584 and 3,3- or 4,4-diphenylcycloalkylamines
Taniguchi,Okumura,Take,Tsubaki,Terai,Nakanishi,Shiokawa
, p. 71 - 77 (2007/10/02)
This article describes the synthesis of 4,4-diphenyl-2-cycloalkenylamines (3, 5a) including PK584 (S(-)-3a) and 3,3- or 4,4-diphenylcycloalkylamines (2, 4, 5b), and their inhibitory activities against detrusor contraction. The order of inhibitory activity
