895155-95-0

Usage

Uses

Used in Pharmaceutical Research:
UR-144 N-(5-Hydroxypentyl) is used as a research compound for studying the effects and mechanisms of action of cannabinoids on the CB1 and CB2 receptors. This helps in understanding the potential therapeutic applications of cannabinoids in various medical conditions.
Used in Recreational Drug Use:
UR-144 N-(5-Hydroxypentyl) is used as a recreational drug, producing euphoric and hallucinogenic effects similar to those of marijuana. However, its use has been associated with adverse effects such as addiction, psychosis, and dependence.
Note: The use of UR-144 N-(5-Hydroxypentyl) as a recreational drug is not recommended due to its potential for abuse and harmful side effects. It is important to follow the laws and regulations regarding the use of controlled substances in your country.

Upstream product

• 4541-15-5 5-(benzyloxy)-1-pentanol 
• 24303-61-5 2,2,3,3-tetramethylcyclopropanecarbonyl chloride 
• 15641-58-4 2,2,3,3-tetramethylcyclopropane-1-carboxylic acid 
• 895152-66-6 (1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone 
• 186374-96-9 5-(benzyloxy)pentyl methanesulfonate 

Relevant academic research and scientific papers

Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activity

Several 3-acylindoles with high affinity for the CB2 cannabinoid receptor and selectivity over the CB1 receptor have been prepared. A variety of 3-acyl substituents were investigated, and the tetramethylcyclopropyl group was found to lead to high affinity CB2 agonists (5, 16). Substitution at the N1-indole position was then examined. A series of aminoalkylindoles was prepared and several substituted aminoethyl derivatives were active (23-27, 5) at the CB2 receptor.Astudy of N1 nonaromatic side chain variants provided potent agonists at the CB2 receptor (16, 35-41, 44-47, 49-54, and 57-58). Several polar side chains (alcohols, oxazolidinone) were well-tolerated for CB2 receptor activity (41, 50), while others (amide, acid) led to weaker or inactive compounds (55 and 56). N1 aromatic side chains also afforded several high affinity CB2 receptor agonists (61, 63, 65, and 69) but were generally less potent in an in vitro CB2 functional assay than were nonaromatic side chain analogues.

3-CYCLOALKYLCARBONYL INDOLES AS CANNABINOID RECEPTOR LIGANDS

The present invention provides novel compounds of Formula (I), which are CB2 selective ligands useful for the treatment of pain.