89523-60-4Relevant academic research and scientific papers
Allicin and derivates are cysteine protease inhibitors with antiparasitic activity
Waag, Thilo,Gelhaus, Christoph,Rath, Jennifer,Stich, August,Leippe, Matthias,Schirmeister, Tanja
, p. 5541 - 5543 (2010)
Allicin and derivatives thereof inhibit the CAC1 cysteine proteases falcipain 2, rhodesain, cathepsin B and L in the low micromolar range. The structure-activity relationship revealed that only derivatives with primary carbon atom in vicinity to the thiosulfinate sulfur atom attacked by the active-site Cys residue are active against the target enzymes. Some compounds also show potent antiparasitic activity against Plasmodium falciparum and Trypanosoma brucei brucei.
Selective Oxidation of Sulphides and Disulphides
Rajanikanth, B.,Ravindranath, B.
, p. 877 - 878 (2007/10/02)
Monoperphthalic acid has been found to be very efficient and convenient reagent for the oxidation of a variety of dialkylsulphides and dialkyl disulphides yielding sulphoxides and thiosulphinates respectively.Thiosulphinates have been prepared selectively
