89531-61-3

Upstream product

• 143425-05-2 dimethyl 4-hydroxy-N-methoxycarbonyl-piperidine-2,2-dicarboxylate 
• 143577-39-3 4-oxo-piperidine-2-carboxylic acid hydrobromide 
• 143424-80-0 dimethyl N-methoxycarbonyl-4-oxo-piperidine-2,2-dicarboxylate 
• 143424-94-6 dimethyl 4-t-butyldimethylsiloxy-N-methoxycarbonyl-1,2,3,6-tetrahydropyridine-2,2-carboxylate 

Downstream Products

• 106275-36-9 cis-4-hydroxy-N-tosyl-piperidine-2-carboxylic acid 
• 106275-36-9 trans-4-hydroxy-N-tosyl-piperidine-2-carboxylic acid 
• 143425-07-4 2-tosyl-6-oxa-2-azabicyclo<3.2.1>octane-7-one 
• 143425-08-5 cis-2-hydroxymethyl-N-tosyl-piperidine-4-ol 
• 143425-10-9 benzyl 7-oxo-6-oxa-2-azabicyclo<3.2.1>octane-1-carboxylate 

Relevant academic research and scientific papers

Amino acids, XII: (±)Pipecolic acid derivatives - Part 2: An expedient synthetic entry to substituted pipecolic acids

The Diels-Alder product 1 is transformed by Noyori reaction and catalytic hydrogenation to 4. Hydrolysis with concomitant decarboxylation of 4 furnishes the trans configuration amino acid 5. Functional group transformation (reduction, lactonization) of 5