89532-98-9Relevant articles and documents
Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.
Murray, Paul E,McNally, Virginia A,Lockyer, Stacey D,Williams, Kaye J,Stratford, Ian J,Jaffar, Mohammed,Freeman, Sally
, p. 525 - 530 (2007/10/03)
A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the most active. 1-[(5-Chloro-2,4-dihydroxypyrimidin-6-yl)methyl]pyridinium chloride, was identified as the best inhibitor being 5-fold more potent than the known inhibitor, 6-amino-5-bromouracil.