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89533-28-8

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89533-28-8 Usage

General Description

4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE is a chemical compound that consists of a pyrimidine ring with an amino group at the 4th position, a methylthio group at the 2nd position, and a carboxamide group at the 5th position. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE has potential applications in the treatment of various diseases and as a precursor in organic synthesis. Its properties and reactivity make it a valuable building block in the production of diverse compounds with important industrial and medical uses.

Check Digit Verification of cas no

The CAS Registry Mumber 89533-28-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,5,3 and 3 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 89533-28:
(7*8)+(6*9)+(5*5)+(4*3)+(3*3)+(2*2)+(1*8)=168
168 % 10 = 8
So 89533-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H8N4OS/c1-12-6-9-2-3(5(8)11)4(7)10-6/h2H,1H3,(H2,8,11)(H2,7,9,10)

89533-28-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-amino-2-methylsulfanylpyrimidine-5-carboxamide

1.2 Other means of identification

Product number -
Other names 4-amino-2-methylsulfanyl-pyrimidine-5-carboxylic acid amide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89533-28-8 SDS

89533-28-8Downstream Products

89533-28-8Relevant articles and documents

Pyridopyrimidinone derivatives as potent and selective c-jun N-terminal kinase (JNK) inhibitors

Zheng, Ke,Park, Chul Min,Iqbal, Sarah,Hernandez, Pamela,Park, Hajeung,Lograsso, Philip V.,Feng, Yangbo

supporting information, p. 413 - 418 (2015/04/27)

A novel series of 2-aminopyridopyrimidinone based JNK (c-jun N-terminal kinase) inhibitors were discovered and developed. Structure-activity relationships (SARs) were systematically developed utilizing biochemical and cell based assays and in vitro and in vivo drug metabolism and pharmacokinetic (DMPK) studies. Through the optimization of lead compound 1, several potent and selective JNK inhibitors with high oral bioavailability were developed. Inhibitor 13 was a potent JNK3 inhibitor (IC50 = 15 nM), had high selectivity against p38 (IC50 > 10 μM), had high potency in functional cell based assays, and had high stability in human liver microsome (t1/2 = 76 min), a clean CYP-450 inhibition profile, and excellent oral bioavailability (%F = 87). Moreover, cocrystal structures of compounds 13 and 22 in JNK3 were solved at 2.0 ?. These structures elucidated the binding mode (Type-I binding) and can pave the way for further inhibitor design of this pyridopyrimidinone scaffold for JNK inhibition.

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