895331-28-9

Basic information

• Product Name: 6-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
• Synonyms: 6-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
• CAS NO: 895331-28-9
• Molecular Formula: C₉H₅BrN₄S
• Molecular Weight: 281.1318
• Mol File: 895331-28-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole(895331-28-9)
• EPA Substance Registry System: 6-(4-bromophenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole(895331-28-9)

Safety Data

• Hazardous Substances Data: 895331-28-9(Hazardous Substances Data)

Upstream product

• 586-76-5 4-Bromobenzoic acid 
• 4343-75-3 4-amino-3-mercapto-1,2,4-triazole 

Relevant articles and documents

Synthesis and anticonvulsant activities of some triazolothiadiazole derivatives

The present study describes the synthesis and anticonvulsant activity evaluation of 6-substituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a-4x) and their partially dehydrogenated products 5,6-dihydro-6-substituted- [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (5a-5n). The bioevaluation demonstrated that most compounds in the series of 4a-4x exhibited potent anticonvulsant activity in the maximal electroshock test. Among which, 6-(4-chlorophenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole (4h) emerged as the most promising candidate on the basis of its favorable ED50 value of 23.7 mg/kg and PI value of 10.8. In addition, the potency of compound 4h against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline in the chemical-induced seizure tests suggested that compound 4h displayed broad-spectrum activity in several models, and it may exert its anticonvulsant activity through affecting the GABAergic system. The anticonvulsant activities of 6-substituted-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazole derivatives (4a-4x) and their partially dehydrogenated products 5,6-dihydro-6-substituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (5a-5n) were evaluated. Most compounds in the series of 4a-4x exhibited potent anticonvulsant activity in the maximal electroshock test. 6-(4-Chlorophenyl)-[1, 2,4]triazolo[3,4-b][1,3,4]thiadiazole (4h) emerged as the most promising candidate on the basis of its favorable ED50 value of 23.7 mg/kg and PI value of 10.8. Copyright