89537-08-6

Basic information

• Product Name: Boc-MeLeu-MeLeu-MeVal-OBzl
• Synonyms: Boc-MeLeu-MeLeu-MeVal-OBzl
• CAS NO: 89537-08-6
• Molecular Weight: 575.789
• Mol File: 89537-08-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Boc-MeLeu-MeLeu-MeVal-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-MeLeu-MeLeu-MeVal-OBzl(89537-08-6)
• EPA Substance Registry System: Boc-MeLeu-MeLeu-MeVal-OBzl(89537-08-6)

Safety Data

• Hazardous Substances Data: 89537-08-6(Hazardous Substances Data)

Upstream product

• 799779-66-1 (S)-2-Isocyano-3-methyl-butyric acid benzyl ester 
• 89536-99-2 benzyl (S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)-N,4-dimethylpentanamido)-3-methylbutanoate 
• 1356155-99-1 Boc-MeLeu-SH 
• 89537-11-1 Boc-MeLeu-MeLeu-OH 
• 89537-10-0 Boc-MeLeu-MeLeu-OBzl 
• 45170-31-8 Boc-N-Me-Val-OH 
• 48168-99-6 N-methyl-L-leucine benzyl ester 
• 53363-89-6 N-t-butoxycarbonyl-N-methyl-L-leucine 
• 81135-38-8 benzyl (2S)-3-methyl-2-(methylamino)butanoate 

Downstream Products

• 89537-09-7 H-MeLeu-MeLeu-MeVal-OBzl 

Relevant articles and documents

Expanding the limits of isonitrile-mediated amidations: On the remarkable stereosubtleties of macrolactam formation from synthetic seco -cyclosporins

The scope of isonitrile-mediated amide bond-forming reactions is further explored in this second-generation synthetic approach to cyclosporine (cyclosporin A). Both type I and type II amidations are utilized in this effort, allowing access to epimeric cyclosporins A and H from a single precursor by variation of the coupling reagents. This work lends deeper insight into the relative acylating ability of the formimidate carboxylate mixed anhydride (FCMA) intermediate, while shedding light on the far-reaching impact of remote stereochemical changes on the effective preorganization of seco-cyclosporins.