89537-18-8

Upstream product

• 108415-26-5 N-(2-Oxopropionyl)prolin-benzylester 
• 32302-87-7 L?proline benzyl ester p?toluenesulfonate 
• 867-56-1 sodium L-lactate 
• 41324-66-7 H-Pro-OBzl 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 

Downstream Products

• 106019-38-9 (S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 106019-39-0 (S)-1-{(S)-2-[Hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-propionyl}-pyrrolidine-2-carboxylic acid benzyl ester; compound with adamantan-1-ylamine 
• 89537-15-5 (S)-1-[2-[[Hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxopropyl]-L-proline, dilithium salt 
• 106019-31-2 (4-Phenyl-butyl)-phosphonic acid monobenzyl ester; compound with adamantan-1-ylamine 
• 106019-30-1 (4-phenylbutyl)phosphonic acid benzyl ester 

Relevant academic research and scientific papers

Amino Acid Esters as Chiral Auxiliaries in Barbier-Type Reactions in Aqueous Solution

Valine and proline benzyl ester are converted into the aliphatic and aromatic α-oxo amides 5 by activation of the respective α-oxo acid by means of N,N'-diisopropylcarbodiimide.The α-oxo amides 5 undergo Barbier-type reactions with differently substituted

(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]- -proline, a novel orally active inhibitor of ACE

The synthesis of a series of orally active, phosphinyloxyacyl proline inhibitors of angiotensin converting enzyme (ACE) is described. The in vitro and in vivo ACE inhibitory activities are reported for each compound. The structure-activity relationship fo

SYNTHESIS OF PHOSPHONIC MONOESTERS FROM PHOSPHONOUS ACIDS

Phosphonic monoesters are prepared in a two-step procedure by DCC-DMAP mediated esterification of phosphonous acids and oxidation of the resulting phosphonous monoester.