895519-84-3

Upstream product

• 186593-42-0 3-bromo-2-methyl-5-nitropyridine 
• 895519-81-0 2-methyl-5-amino-3-(4-pyridin-3-yl)pyrimidin-2-ylamino-pyridine 
• 895519-97-8 4-((4-ethylpiperazin-1-yl)methyl)benzoic acid 
• 66521-66-2 4-pyridin-3-ylpyrimidin-2-ylamine 

Relevant academic research and scientific papers

NOVEL HETEROCYCLE COMPOUNDS AND USES THEREOF

The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (Q) or (I), which penetrate the blood-brain barrier, inhibit the formation and accumulation of beta- amyloid, and are useful in the treatment of neurodegenerative diseases, particularly Alzheimer's disease. Further, the compounds of the present invention inhibit certain kinases, thereby being useful for the treatment of cancers of the central nervous system.

AMINOPYRIMIDINE COMPOUNDS AND THEIR SALTS, PROCESS FOR PREPARATION AND PHARMACEUTICAL USE THEREOF

The present invention provides aminopyrimidine compounds of formula (I) and their salts, wherein R1, R2, R3, R4, R5, R6, Q, Z, L, m, n are defined as the description, the methods for preparation thereof, the uses thereof and the pharmaceutical compositions comprising the effective amount of compounds of formula (I). The compounds of formula (I) and their salts can be used as protein kinase inhibitors.