89556-08-1Relevant academic research and scientific papers
Solvent-Free and Liquid-Phase Iodination of Thiophene Derivatives with Potassium Dichloroiodate Monohydrate
Hussain, Anwar,Sarkar, Akash Mamon,Sereda, Grigoriy,Zefirov, Nikolai
, p. 1140 - 1146 (2020/04/01)
Iodination of a series of benzene and thiophene derivatives by potassium dichloroiodate monohydrate was studied with and without a solvent. The liquid substrates tend to be more reactive in water while the solid substrates afford better yields in dichloromethane or under the solvent-free conditions. The 2-substituted thiophenes show good to excellent yields whereas the yield for 3-substituted and 3,4- or 2,4-disubstituted thiophenes and benzene derivatives are significantly lower. The mechanochemical reaction of 5-carbaldehyde-2,2′-bithiophene shows excellent yields, while 2,2′-bithiophene gives practical yields only in dichloromethane. In the case of thiophene and N -acetyl- p -toluidine, electrophilic iodination is accompanied by a small extent of chlorination.
Clean and Efficient Iodination of Thiophene Derivatives
Grolleau, Jérémie,Frère, Pierre,Gohier, Frédéric
, p. 3901 - 3906 (2015/12/18)
Iodination of thiophene derivatives is realized using a simple, fast, and efficient methodology. Iodination of thiophene and 2- or 3-substituted or 3,4-disubstituted thiophenes with N-iodosuccinimide (NIS) activated with 4-toluenesulfonic acid in ethanol gives pure iodinated products that require no further purification.
Preparation of unsymmetrical 1,4-bis[2-ethynyl-3-thienyl]benzene derivative
Toyota, Kozo,Tsuji, Yasutomo,Okada, Kazuyuki,Morita, Noboru
experimental part, p. 127 - 138 (2009/05/07)
Unsymmetrically substituted 1,4-bis(2-ethynyl-3-thienyl)benzene derivative was prepared, utilizing 1-bromo-4-(2-iodo-3-thienyl)benzene and 5-alkyl-3-bromo-2-ethynylthiophene derivatives as key intermediates.
