895569-73-0

Basic information

• Product Name: 4-[2-(2,4-difluoro-phenyl)-ethyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester
• CAS NO: 895569-73-0
• Molecular Weight: 341.398
• Mol File: 895569-73-0.mol

Chemical Properties

• CAS DataBase Reference: 4-[2-(2,4-difluoro-phenyl)-ethyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(2,4-difluoro-phenyl)-ethyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester(895569-73-0)
• EPA Substance Registry System: 4-[2-(2,4-difluoro-phenyl)-ethyl]-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester(895569-73-0)

Safety Data

• Hazardous Substances Data: 895569-73-0(Hazardous Substances Data)

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 

Downstream Products

• 895569-72-9 4-[2-(2,4-difluoro-phenyl)-ethyl]-1-(4-fluoro-benzenesulfonyl)-piperidin-4-ol 

Relevant articles and documents

A new class of selective, non-basic 5-HT2A receptor antagonists

Based on an existing series of 5-HT2A receptor ligands containing a basic nitrogen, we designed a non-basic lead that had reduced affinity for both the 5-HT2A receptor and the IKr potassium channel. The present paper describes the development of this lead to a novel series of non-basic piperidine sulfonamides and amides that have high affinity for the 5-HT2A receptor, whilst maintaining excellent selectivity over off target activities such as the IKr channel. This work has shown that the proposed pharmacaphore model for the 5-HT2A receptor which suggests that a basic nitrogen is required for the binding of ligands is questionable.