895571-98-9

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 536747-52-1 1-(4-amino-3-fluoro-phenyl)-pyridin-2-one 

Downstream Products

• 895571-99-0 [2-fluoro-4-(2-oxo-pyridin-1-yl)-phenyl]-2-(3-nitro-2-oxo-pyridin-1-yl)-acetamide 
• 913743-18-7 (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl-carbamoyl]-methyl}-pyrrolidine-3-carboxylic acid ethyl ester 
• 913743-07-4 5-chloro-thiophene-2-carboxylic acid ((S)-4-fluoro-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarba-moyl]-methyl}-pyrrolidin-3-yl)-amide 

Relevant academic research and scientific papers

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit

Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.

Heteroarylacetamide inhibitors of factor Xa

The invention is concerned with novel heteroarylacetamides of formula (I) [in-line-formulae]Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb) ??(I) [/in-line-formulae] wherein Ra to Re /

Cyclic amines

The invention is concerned with cyclic amines of formula (I) wherein X1 to X3, Y1 to Y3, R1′, R1″ and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit coagulation factor Xa and can be used as medicaments and for treating diseases associated with coagulation factor Xa.