89565-76-4

Upstream product

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 501-53-1 benzyl chloroformate 
• 65-49-6 4-Aminosalicylic acid 
• 6935-15-5 4‐{[(benzyloxy)carbonyl]amino}‐2‐hydroxybenzoic acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 27492-84-8 Methyl 4-amino-2-methoxybenzoate 
• 1391921-95-1 N-(4-methoxycarbonyl-3-methoxyphenylcarbamoylmethyl)-N,N',N'',N''-diethylenetriaminetetraacetic acid 

Relevant academic research and scientific papers

Salicylic-acid derivatives as antennae for ratiometric luminescent probes based on lanthanide complexes

Long-lived ratiometric sensors: Luminescent lanthanide complexes are widely used in time-resolved assays of biomolecules, but most of the sensors with these complexes rely on single-point intensity measurements. Herein, we introduce a simple strategy to create ratiometric probes by using salicylic-acid derivatives as the antenna moiety of Tb3+ complexes. As an example, a probe for alkaline phosphatase (ALP) was developed (see scheme). Copyright

Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography

In a search for high-affinity receptor ligands that might serve for development as radioligands for the imaging of brain 5-HT4 receptors in vivo with positron emission tomography (PET), structural modifications were made to the high-affinity 5-HT4 antagonist (1-butylpiperidin-4-yl) methyl 8-amino-7-iodo-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate (1, SB 207710). These modifications were made mainly on the aryl side of the ester bond to permit possible rapid labeling of the carboxylic acid component with a positron emitter, either carbon-11 (t1/2 = 20.4 min) or fluorine-18 (t1/2 = 109.7 min), and included (i) replacement of the iodine atom with a small substituent such as nitrile, methyl, or fluoro, (ii) methylation of the 8-amino group, (iii) opening of the dioxan ring, and (iv) alteration of the length of the N-alkyl goup. High-affinity ligands were discovered for recombinant human 5-HT4 receptors with amenability to labeling with a positron emitter and potential for development as imaging probes. The ring-opened radioligand, (([methoxy-11C]1-butylpiperidin-4-yl)methyl 4-amino-3-methoxybenzoate; [11C]13), showed an especially favorable array of properties for future evaluation as a PET radioligand for brain 5-HT4 receptors. This article not subject to U.S. Copyright. Published 2010 by the American Chemical Society.