89569-02-8

Upstream product

• 89569-00-6 3,4-dihydro-2-phenyl-2H-1,6-benzothiazocin-5(6H)-thione 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 51085-65-5 4-(o-aminophenylthio)-4-phenylbutyric acid 
• 1672-37-3 3,4-dihydro-2-phenyl-2H-1,6-benzothiazocin-5(6H)-one 

Downstream Products

• 89569-06-2 3,4-dihydro-2-phenyl-5-(1-pyrrolidinyl)-2H-1,6-benzothiazocine 
• 89569-07-3 3,4-dihydro-5-(1-morpholino)-2-phenyl-2H-1,6-benzothiazocine 
• 89569-11-9 4-(o-aminophenythio)-N-butyl-4-phenylbutyramide 
• 89569-08-4 3,4-dihydro-5-methylamino-2-phenyl-2H-1,6-benzothiazocine 
• 89569-04-0 3,4-dihydro-5-(4-methyl-1-piperazinyl)-2-phenyl-2H-1,6-benzothiazocine 

Relevant academic research and scientific papers

Process for the ring chlorination of aromatic hydrocarbons

Aromatic hydrocarbons which are monosubstituted by straight-chain or branched C1 -C12 -alkyl or by C3 -C8 -cycloalkyl can be chlorinated in the presence of Friedel-Crafts Catalysts in liquid phase on the aromatic ring if cyclic benzo-fused imines or benzo[f]-1,4-thiazepines are used as co-catalysts. This makes it possible to obtain a higher proportion of p-isomers.

Synthesis of 2-Phenyl-3,4-dihydro-2H- and -3,4,5,6-tetrahydro-2H-1,6-benzothiazocine Derivatives

The resynthesis of 2-phenyl-3,4-dihydro-2H-benzothiazocin-5(6H)-one (1) was investigated in order to prepare derivatives with potential CNS activity.Lactam 1 could be converted to amidine derivatives 6a-e via the intermediacy of the thioether 5a.Reduction