89570-82-1

Basic information

• Product Name: 3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE
• Synonyms: [3-Chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazine, 5-Chloro-6-hydrazino-alpha,alpha,alpha-trifluoro-3-picoline;BUTTPARK 24\07-70;1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDYL]HYDRAZINE;AKOS BBS-00006490;3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE;3-CHLORO-2-HYDRAZINO-5-(TRIFLUOROMETHYL)PYRIDINE;3-Chloro-5-(trifluoromethyl)pyridin-2-ylhydrazine;3-Chloro-5-(trifluoromethyl)pyridin-2-ylhydrazine 97%
• CAS NO: 89570-82-1
• Molecular Formula: C₆H₅ClF₃N₃
• Molecular Weight: 211.57
• Product Categories: Halides;Pyridines
• Mol File: 89570-82-1.mol

Chemical Properties

• Melting Point: 90 °C
• Boiling Point: 238.7 °C at 760 mmHg
• Flash Point: 98.1 °C
• Appearance: /
• Density: 1.57 g/cm³
• Vapor Pressure: 0.042mmHg at 25°C
• Refractive Index: 1.547
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.83±0.70(Predicted)
• CAS DataBase Reference: 3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE(89570-82-1)
• EPA Substance Registry System: 3-CHLORO-5-(TRIFLUOROMETHYL)PYRID-2-YLHYDRAZINE(89570-82-1)

Safety Data

• Hazard Codes: Xi,T
• Statements: 20/21/22-36/37/38-25
• Safety Statements: 20/21-36/37/39-45
• HazardClass: IRRITANT
• Hazardous Substances Data: 89570-82-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-5-(trifluoromethyl)pyrid-2-ylhydrazine is used as a synthetic intermediate for the development of pharmaceuticals. Its potential pharmacological activities as an antifungal and antibacterial agent make it a valuable compound for creating new medications to combat various infections.
Used in Agrochemical Industry:
In the agrochemical industry, 3-chloro-5-(trifluoromethyl)pyrid-2-ylhydrazine is used as a synthetic intermediate for the production of agrochemicals. Its antifungal and antibacterial properties can be utilized in the development of pesticides and other agricultural chemicals to protect crops from diseases and pests, thereby increasing agricultural productivity.

InChI:InChI=1/C6H5ClF3N3/c7-4-1-3(6(8,9)10)2-12-5(4)13-11/h1-2H,11H2,(H,12,13)

Upstream product

• 69045-84-7 2,3-dichloro-5-trifluoromethylpyridine 
• 69045-83-6 2,3-dichloro-5-(trichloromethyl)pyridine 

Downstream Products

• 235789-29-4 methyl 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-5-phenylpyrazole-3-carboxylate 
• 235789-46-5 4-chloro-1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-5-phenyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 173213-31-5 N-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-N'-pyridin-2-ylmethylene-hydrazine 
• 148837-76-7 1-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-4-ethoxycarbonyl-1H-5-methylpyrazole 
• 338397-51-6 N',1-bis(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-pyrrole-2-carbohydrazide 
• 135782-72-8 8-chloro-3-(4-nitrophenyl)-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS

The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Compound containing 3-chloro-5-trifluoromethylpyridyl-1,3,4-oxadiazole-2-one and application thereof

The invention discloses a compound containing 3-chloro-5-trifluoromethylpyridyl-1,3,4-oxadiazole-2-one. A general molecular formula is shown as I: the formula I is shown in the description; in the general formula I, R is selected from formulas shown in the description. The compound with the general formula I has good bioactivity on pests in agriculture, such as plutella xylostella, beet armyworm,tetranychus cinnabarinus and panonychus citri mcgregor and can be used for preventing and controlling the pests and pest mites in agriculture.

Structure-based discovery and synthesis of potential transketolase inhibitors

Transketolase (TKL) plays a key role in plant photosynthesis and has been predicted to be a potent herbicide target. Homology modeling and molecular dynamics simulation were used to construct a target protein model. A target-based virtual screening was developed to discover novel potential transketolase inhibitors. Based on the receptor transketolase 1 and a target-based virtual screening combined with structural similarity, six new compounds were selected from the ZINC database. Among the structural leads, a new compound ZINC12007063 was identified as a novel inhibitor of weeds. Two novel series of carboxylic amide derivatives were synthesized, and their structures were rationally identified by NMR and HRMS. Biological evaluation of the herbicidal and antifungal activities indicated that the compounds 4u and 8h were the most potent herbicidal agents, and they also showed potent fungicidal activity with a relatively broad-spectrum. ZINC12007063 was identified as a lead compound of potential transketolase inhibitors, 4u and 8h which has the herbicidal and antifungal activities were synthesized based on ZINC12007063. This study lays a foundation for the discovery of new pesticides.

Microwave assisted synthesis and antifungal activity of some novel hydrazones containing pyridine moiety

A series of novel hydrazone derivatives containing pyridine moiety were designed and synthesized from 2,3-dichloro-5-(trifluoromethyl)pyridine as starting materials under microwave irradiation, and their structures were characterized by 1H NMR, MS and elemental analysis. The biological activity of title compounds was determined. The results indicated that some of title compounds exhibited good antifungal activity.

3-Chloro-2-hydrazino-5-trifluoromethylpyridine derivative, and preparation method and application thereof

The invention relates to a 3-chloro-2-hydrazino-5-trifluoromethylpyridine derivative, and a preparation method and an application thereof. A series of new compounds are synthesized through a microwave assisted simple technology. The method has the advantages of simple and easily available raw material, convenience for operation, fast heating and great shortening of the reaction time due to adoption of a microwave assisted reaction, yield increase and environmental protection. The above compounds have a good inhibition effect on tomato bacterial leaf spot under a concentration of 100[mu]g/ml, and the inhibition rate reaches up to 79.76%; the compounds have a good inhibition effect on cucumber fusarium wilt, and the inhibition rate reaches up to 63.33%; and the compounds are new compounds with sterilization activity, and provide a basis for development of new pesticides.

HETEROCYCLIC COMPOUND

The present invention provides a compound or a salt thereof useful for an agent for the prophylaxis or treatment of neurodegenerative disease and the like. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.

HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of GPR119 for the treatment or prevention of metabolic, cardiovascular, and metabolic diseases.

Synthesis of 1,3-diazepines and ring contraction to cyanopyrroles

Several tetrazolo[1,5-a]pyridines/2-azidopyridines undergo photochemical nitrogen elimination and ring expansion to 1,3-diazacyclohepta-1,2,4, 6-tetraenes (7,10,13,16,19,22) as well as ring cleavage to cyanovinylketenimines (8,17,20b) in low temperature Ar matrices. 6,8-Dichlorotetrazolo[1,5-a]pyridine/2-azido-3,5-dichloropridine 6 undergoes ready exchange of the chlorine in position 8 (3) with ROH/RONa. 8-Chloro-6-trifluoromethylletrazolo[1,5-a]pyridine 15 undergoes solvolysis of the CF3 group to afford 8-chloro-6-methoxycarbonyltetrazolo[1,5-a]pyridine 18. Several tetrazolopyridines/2-azidopyridines afford 1H- or 5H-1,3-diazepines in good yields on photolysis in the presence of alcohols or amines (11,14,23,25). 5-Chlorotetrazolo[1,5-a]pyridines/2-azido-6-chloropyridines 21 and 38 undergo a rearrangement to 1H-and 3H-3-cyanopyrroles 27 and 45, respectively. The mechanism of this rearrangement was investigated by 15N-labelling and takes place via transient 1,3-diazepines. The structures of 6,8-dichloro-tetrazolo[1,5-a]pyridine 6T, 6-chloro-8-ethoxytetrazoIo[1,5-a]pyridine 9Tb, dipyrrolylmethane 28, and 2-isopropoxy-4-dimethylamino-5H-1,3-diazepine 25b were determined by X-ray crystallography. In the latter case, this represents the first reported X-ray crystal structure of a 5H-1,3-diazepine.

Herbicidal derivatives of 2-(1-aryl-4-cyano-5-pyrazolylmethyleneiminooxy)alkanoic acids

Herbicidal compounds, compositions containing them, and a method for controlling weeds by application of the compositions are disclosed. The herbicidal compounds are 2-(1-aryl-4-cyano-5-pyrazolylmethyleneiminooxy)alkanoic acid derivatives of the structure