89581-50-0

Basic information

• Product Name: ortho-bromobenzenesulfinic acid
• Synonyms: ortho-bromobenzenesulfinic acid
• CAS NO: 89581-50-0
• Molecular Weight: 221.075
• Mol File: 89581-50-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: ortho-bromobenzenesulfinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ortho-bromobenzenesulfinic acid(89581-50-0)
• EPA Substance Registry System: ortho-bromobenzenesulfinic acid(89581-50-0)

Safety Data

• Hazardous Substances Data: 89581-50-0(Hazardous Substances Data)

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 615-36-1 2-bromoaniline 
• 17333-81-2 o-bromobenzenediazonium 

Downstream Products

• 508233-74-7 vortioxetine 
• 960203-27-4 Vortioxetine hydrobromide 
• 1571792-29-4 (E)-1-bromo-2-(styrylsulfonyl)benzene 
• 1613024-21-7 C₁₇H₁₆BrNO₃S 
• 7321-58-6 (S)-methyl o-bromophenyl sulfoxide 

Relevant articles and documents

tert-Butyl Hydroperoxide-Initiated Radical Cyclization of 1-(Allyloxy)-2-(1-Arylvinyl)Benzenes with Sulfinic Acids to Access Sulfonated Benzoxepines

A tert-butyl hydroperoxide-initiated radical cyclization of 1-(allyloxy)-2-(1-arylvinyl)benzenes with sulfinic acids for the construction of sulfonated benzoxepines is developed. This reaction involves a radical pathway and offers a straightforward route to the formation of seven-membered ring via sulfonylation/cyclization process. This methodology features mild reaction conditions, a broad substrate scope and good functional group tolerance. (Figure presented.).

Preparation method of vortioxetine and intermediate thereof

The invention discloses a preparation method of vortioxetine and an intermediate thereof. The invention provides a preparation method of a vortioxetine intermediate IV, wherein the preparation methodcomprises the following steps: performing Grignard reaction on a vortioxetine intermediate V and 2,4-dimethyliodobenzene and isopropylmagnesium chloride in an organic solvent to obtain the vortioxetine intermediate IV. The preparation method provided by the invention no longer uses volatile odorous thiophenol derivatives, is environmentally friendly, simple and safe to operate and high in yield; the prepared vortioxetine has high purity, can reach requirements of raw material medicines and is suitable for industrial production.