89586-95-8Relevant articles and documents
Fe3O4@cellulose composite nanocatalyst: Preparation, characterization and application in the synthesis of benzodiazepines
Maleki, Ali,Kamalzare, Maryam
, p. 67 - 71 (2014)
A cellulose-based nanocomposite with highly loaded Fe3O 4 nanoparticles was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR) spectra, scanning electron microscopy (SEM) images, energy-dispersive X-ray spe
A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst
Anal, Jasha Momo H.,Gupta, Ajay,Jamatia, Ramen,Pal, Amarta Kumar,Sarkar, Fillip Kumar
, p. 19553 - 19564 (2021/11/09)
Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT
Method for synthesizing 1,5-benzodiazepine compound
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Paragraph 0037-0040, (2019/12/25)
The invention discloses a method for synthesizing a 1,5-benzodiazepine compound. The method specifically comprises the following steps: dissolving a gold catalyst, an additive, alkyne of a formula IIshown in the specification, an o-phenylenediamine derivative of a formula III shown in the specification into an organic solvent, putting the solution into a pressure-resistant reaction tube, performing a stirring reaction for 6-24 hours at 25 DEG C so as to obtain a reaction liquid, and performing aftertreatment on the reaction liquid so as to obtain the 1,5-benzodiazepine compound of a formula IV shown in the specification, wherein the mass ratio of the gold catalyst of a formula I shown in the specification to the additive to the alkyne of the formula II shown in the specification to the o-phenylenediamine derivative of the formula III shown in the specification is (0.01-0.07):(0-0.1):(2.0-3.0):1. By adopting the method disclosed by the invention, a double-functional catalyst is used, the reaction can be performed under a room temperature condition, and thus energy consumption can be reduced; and the method has the advantages of being small in catalyst amount, high in yield, good insubstrate universality, simple and convenient in operation, and the like.