89586-96-9

Usage

Chemical class

Benzodiazepine

Type of compound

Heterocyclic compound

Structure

Benzene ring fused to a seven-membered diazepine ring

Substituents

Two methoxyphenyl groups and a methyl group attached to the diazepine ring

Pharmacological properties

Potential anxiolytic, sedative, and hypnotic effects

Further research

Required to fully understand the potential uses and effects of this chemical
Please note that this information is based on the provided material, and further research is needed to confirm the properties and effects of this specific benzodiazepine derivative.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 768-60-5 4-methoxyphenylacetylen 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1516-58-1 o-azidonitrobenzene 
• 39145-59-0 o-phenylenediamine hydrochloride 

Relevant academic research and scientific papers

A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst

Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT

Method for preparing benzodinitrogen compound by using gold complex

The invention relates to a method for preparing a benzodinitrogen compound by using a gold complex, which comprises the following step of: reacting an o-phenylenediamine compound and alkyne as raw materials with a gold complex containing a diphosphine ort

One-pot, water-mediated, H2O2-HCl catalyzed synthesis of benzazepines

One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted keton

Method for synthesizing 1,5-benzodiazepine compound

The invention discloses a method for synthesizing a 1,5-benzodiazepine compound. The method specifically comprises the following steps: dissolving a gold catalyst, an additive, alkyne of a formula IIshown in the specification, an o-phenylenediamine derivative of a formula III shown in the specification into an organic solvent, putting the solution into a pressure-resistant reaction tube, performing a stirring reaction for 6-24 hours at 25 DEG C so as to obtain a reaction liquid, and performing aftertreatment on the reaction liquid so as to obtain the 1,5-benzodiazepine compound of a formula IV shown in the specification, wherein the mass ratio of the gold catalyst of a formula I shown in the specification to the additive to the alkyne of the formula II shown in the specification to the o-phenylenediamine derivative of the formula III shown in the specification is (0.01-0.07):(0-0.1):(2.0-3.0):1. By adopting the method disclosed by the invention, a double-functional catalyst is used, the reaction can be performed under a room temperature condition, and thus energy consumption can be reduced; and the method has the advantages of being small in catalyst amount, high in yield, good insubstrate universality, simple and convenient in operation, and the like.

Graphite oxide: A metal free highly efficient carbocatalyst for the synthesis of 1,5-benzodiazepines under room temperature and solvent free heating conditions

Graphite Oxide (GO), an attractive metal free carbocatalyst, was employed as a green and highly efficient catalytic system for the synthesis of 1,5-benzodiazepines. The reaction was studied at room temperature as well as at 80°C under solvent free heating

Microwave-Assisted, solvent free preparation of 1,5-benzodiazepine derivatives using nanomagnetic-supported sulfonic acid as a recyclable and heterogeneous catalyst

A new preparation of 1,5-benzodiazepine derivatives has been achieved in good to excellent yields by the condensation of o-phenylenediamine with a variety of ketones employing nano-Fe2O3-SO3H as catalyst under microwave irradiation and solvent-free condit

An efficient facile and one-pot synthesis of benzodiazepines and chemoselective 1,2-disubstituted benzimidazoles using a magnetically retrievable Fe3O4 nanocatalyst under solvent free conditions

Benzodiazepine and chemoselective 1,2-disubstituted benzimidazole derivatives were synthesized by the condensation reaction of o-phenylenediamine with ketones and aryl aldehydes using Fe3O4 nanoparticles as a recyclable catalyst unde

Synergistic catalysis by an aerogel supported ionic liquid phase (ASILP) in the synthesis of 1,5-benzodiazepines

An ionic liquid film of [Bmim]Cl containing an organometallic catalyst (Cp2ZrCl2) has been anchored on the porous matrix of an aerogel by adsorption interactions. The synthesized aerogel supported ionic liquid phase catalyst was succ

Gold(I)-catalyzed synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes

A unique gold(I)-catalyzed highly atom-economic synthesis of 1,5-benzodiazepines directly from o-phenylenediamines and alkynes has been achieved for the first time.

Terminal alkynes as keto-methyl equivalent toward one pot synthesis of 1,5-benzodiazepine derivatives under catalysis of Hg(OTf)2

Mercuric triflate catalyzes the reaction between 1,2-diaminobenzene and terminal alkynes to afford 2,4-disubstituted 2-methyl-2,3-dihydro-1H-benzo[b][1, 4]diazepine in an excellent yield. The terminal alkynes function as a source of keto-methyl equivalent.