89586-98-1

Basic information

• Product Name: 1H-1,5-Benzodiazepine, 2,4-bis(4-chlorophenyl)-2,3-dihydro-2-methyl-
• CAS NO: 89586-98-1
• Molecular Formula: C22H18Cl2N2
• Molecular Weight: 381.304
• Mol File: 89586-98-1.mol
• Article Data: 31

Chemical Properties

• Melting Point: 160-163 °C(Solv: ethanol (64-17-5))
• Boiling Point: 511.0±50.0 °C(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 1H-1,5-Benzodiazepine, 2,4-bis(4-chlorophenyl)-2,3-dihydro-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-1,5-Benzodiazepine, 2,4-bis(4-chlorophenyl)-2,3-dihydro-2-methyl-(89586-98-1)
• EPA Substance Registry System: 1H-1,5-Benzodiazepine, 2,4-bis(4-chlorophenyl)-2,3-dihydro-2-methyl-(89586-98-1)

Safety Data

• Hazardous Substances Data: 89586-98-1(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 95-54-5 1,2-diamino-benzene 
• 99-91-2 para-chloroacetophenone 
• 1516-58-1 o-azidonitrobenzene 

Downstream Products

• 1176196-29-4 (2S,4S)-2,4-bis(4-chlorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 
• 1176196-04-5 (2S,4R)-2,4-bis(4-chlorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 

Relevant articles and documents

Method for preparing benzodinitrogen compound by using gold complex

The invention relates to a method for preparing a benzodinitrogen compound by using a gold complex, which comprises the following step of: reacting an o-phenylenediamine compound and alkyne as raw materials with a gold complex containing a diphosphine ort

A green synthesis of 1,5-benzodiazepines using reusable-heterogeneous silica sulfuric acid catalyst under solvent-free conditions and their antileukemic activity

1,5-Benzodiazepine derivatives are readily assembled from o-phenylene diamine and ketones containg α-hydrogen atoms by means of simple cyclocondensation via sp3 C-H activation promoted by an efficient heterogeneous silica sulfuric acid catalyst. Eco-friendliness, good yields, easy workup, reusable catalyst, short reaction times, high atom economy and solvent-free conditions are the noteworthy features of this protocol. These benzodiazepines are chosen for the evaluation of antiproliferative activity against different leukemia cell lines. Among the investigated compounds, 3g is the best antiproliferative agent against all the cell lines tested. Also, current preliminary analysis showed that compound 3g phosphorylates ERK1/2 and induces G1 arrest in K562 cells.

One-pot, water-mediated, H2O2-HCl catalyzed synthesis of benzazepines

One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted keton