89586-98-1

Upstream product

• 1516-58-1 o-azidonitrobenzene 
• 99-91-2 para-chloroacetophenone 
• 95-54-5 1,2-diamino-benzene 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 1176196-29-4 (2S,4S)-2,4-bis(4-chlorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 
• 1176196-04-5 (2S,4R)-2,4-bis(4-chlorophenyl)-2-methyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine 

Relevant academic research and scientific papers

A green and sustainable approach for the synthesis of 1,5-benzodiazepines and spirooxindoles in one-pot using a MIL-101(Cr) metal-organic framework as a reusable catalyst

Metal-organic framework MIL-101(Cr) has been efficiently utilized for the synthesis of biologically relevant heterocycles such as 1,5-benzodiazepines and spirooxindoles in one-pot. MIL-101(Cr) was prepared via a solvothermal method and characterized by FT

A green synthesis of 1,5-benzodiazepines using reusable-heterogeneous silica sulfuric acid catalyst under solvent-free conditions and their antileukemic activity

1,5-Benzodiazepine derivatives are readily assembled from o-phenylene diamine and ketones containg α-hydrogen atoms by means of simple cyclocondensation via sp3 C-H activation promoted by an efficient heterogeneous silica sulfuric acid catalyst. Eco-friendliness, good yields, easy workup, reusable catalyst, short reaction times, high atom economy and solvent-free conditions are the noteworthy features of this protocol. These benzodiazepines are chosen for the evaluation of antiproliferative activity against different leukemia cell lines. Among the investigated compounds, 3g is the best antiproliferative agent against all the cell lines tested. Also, current preliminary analysis showed that compound 3g phosphorylates ERK1/2 and induces G1 arrest in K562 cells.

Assessment of elementary derivatives of 1,5-benzodiazepine as anticancer agents with synergy potential

Herein, we designed and synthesized 1,5-benzodiazepines as a lead molecule for anticancer activity and as potent synergistic activity with drug Methotrexate. Working under the framework of green chemistry principles, series of 1,5-benzodiazepine derivativ

Method for preparing benzodinitrogen compound by using gold complex

The invention relates to a method for preparing a benzodinitrogen compound by using a gold complex, which comprises the following step of: reacting an o-phenylenediamine compound and alkyne as raw materials with a gold complex containing a diphosphine ort

One-pot, water-mediated, H2O2-HCl catalyzed synthesis of benzazepines

One-pot, multicomponent H2O2-HCl catalyzed system was employed for the synthesis of a series of benzazepine compounds. The implemented procedure oxidized the carbon-nitrogen bonds and produced benzazepines, while integrating diamines and substituted keton

Method for synthesizing 1,5-benzodiazepine compound

The invention discloses a method for synthesizing a 1,5-benzodiazepine compound. The method specifically comprises the following steps: dissolving a gold catalyst, an additive, alkyne of a formula IIshown in the specification, an o-phenylenediamine derivative of a formula III shown in the specification into an organic solvent, putting the solution into a pressure-resistant reaction tube, performing a stirring reaction for 6-24 hours at 25 DEG C so as to obtain a reaction liquid, and performing aftertreatment on the reaction liquid so as to obtain the 1,5-benzodiazepine compound of a formula IV shown in the specification, wherein the mass ratio of the gold catalyst of a formula I shown in the specification to the additive to the alkyne of the formula II shown in the specification to the o-phenylenediamine derivative of the formula III shown in the specification is (0.01-0.07):(0-0.1):(2.0-3.0):1. By adopting the method disclosed by the invention, a double-functional catalyst is used, the reaction can be performed under a room temperature condition, and thus energy consumption can be reduced; and the method has the advantages of being small in catalyst amount, high in yield, good insubstrate universality, simple and convenient in operation, and the like.

Microwave-Assisted, solvent free preparation of 1,5-benzodiazepine derivatives using nanomagnetic-supported sulfonic acid as a recyclable and heterogeneous catalyst

A new preparation of 1,5-benzodiazepine derivatives has been achieved in good to excellent yields by the condensation of o-phenylenediamine with a variety of ketones employing nano-Fe2O3-SO3H as catalyst under microwave irradiation and solvent-free condit

Green and reusable nanocatalyst for the synthesis of 1,5-benzodiazepines and its derivatives under solvent-free conditions

Novel, reusable, and efficient (Cd, Zn) S nanocatalysts were prepared by simple and economical chemical bath deposition using a greener approach. The as-synthesized catalysts were characterized by XRD, SEM, TEM, and FT-IR spectroscopy. The catalytic activ

Tetraalkylammonium bromate (TAAB) catalyzed cyclodehydration: A facile synthesis of 2,3-dihydro-1H-1,5-benzodiazepine in aqueous methanol

A simple and convenient method is reported for the synthesis of 2,3-dihydro-1H-1,5-benzodiazepine from o-phenylenediamine and ketones in aqueous methanol using IL, tetraalkylammonium bromate, as the cyclodehydration catalyst. The synthetic protocol is sim

Fe3O4@cellulose composite nanocatalyst: Preparation, characterization and application in the synthesis of benzodiazepines

A cellulose-based nanocomposite with highly loaded Fe3O 4 nanoparticles was prepared and characterized by Fourier transform infrared spectroscopy (FT-IR) spectra, scanning electron microscopy (SEM) images, energy-dispersive X-ray spe