89600-99-7Relevant academic research and scientific papers
An efficient multi-component synthesis of N-1-alkylated 5-nitrouracils from α-amino acids
Boiteau, Jean-Guy,Bouix-Peter, Claire,Chambon, Sandrine,Clary, Laurence,Daver, Sebastien,Dumais, Laurence,Fournier, Jean-Fran?ois,Harris, Craig S.,Mebrouk, Kenny,Millois, Corinne,Pierre, Romain,Rodeville, Nicolas,Talano, Sandrine,Tomas, Lo?c
, p. 2367 - 2371 (2016)
The preparation of N-1 selectively alkylated uracil intermediates usually requires selective protection at N-3 followed by alkylation at N-1 and subsequent removal of the protecting group. In this Letter, we show the limitations of this approach when quaternary C centres at N-1 became a key target for the programme. To access this key substructure, we developed an efficient multi-component reaction (MCR) from readily available α-amino acid precursors.
