89607-12-5

Basic information

• Product Name: 4-broMo-1-Methyl-3-nitro-1H-pyrazole
• Synonyms: 4-broMo-1-Methyl-3-nitro-1H-pyrazole
• CAS NO: 89607-12-5
• Molecular Formula: C4H4BrN3O2
• Molecular Weight: 205.99746
• Mol File: 89607-12-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-broMo-1-Methyl-3-nitro-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-1-Methyl-3-nitro-1H-pyrazole(89607-12-5)
• EPA Substance Registry System: 4-broMo-1-Methyl-3-nitro-1H-pyrazole(89607-12-5)

Safety Data

• Hazardous Substances Data: 89607-12-5(Hazardous Substances Data)

Upstream product

• 89717-64-6 4-bromo-3-nitro-1H-pyrazole 
• 77-78-1 dimethyl sulfate 
• 84547-89-7 4-bromo-1-methyl-3-nitropyrazole-5-carboxylic acid 

Downstream Products

• 37921-12-3 1-methyl-3-nitro-4-(p-tolyl)-1H-pyrazole 
• 39205-76-0 4-amino-1-methyl-3-nitropyrazole 
• 54210-32-1 1-methyl-3-nitro-1H-pyrazole 

Relevant articles and documents

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

SYNTHESIS OF 3-AMINO-4-NITROPYRAZOLES

3-Bromo-1,5-dimethyl-4-nitropyrazole does not react upon heating with aqueous ammonia, while 1,5-dimethyl-3,4-dinitropyrazole under the same conditions yields 3-amino-1,5-dimethyl-4-nitropyrazole, which is formed from 3-bromo-1,5-dimethyl-4-nitropyrazole in the presence of a copper catalyst.The amination of 1-methyl-3,4-dinitropyrazole-5-carboxylic acid is accompanied by decarboxylation, which is characteristic for 4-substituted 1-methylpyrazole-5-carboxylic acids upon heating in aqueous ammonia or water.