89609-46-1

Basic information

• Product Name: 1-cyclohexyl-3-(4-methylphenyl)urea
• Synonyms: 1-Cyclohexyl-3-(4-methylphenyl)urea; urea, N-cyclohexyl-N'-(4-methylphenyl)-
• CAS NO: 89609-46-1
• Molecular Formula: C₁₄H₂₀N₂O
• Molecular Weight: 232.3214
• Mol File: 89609-46-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 349.3°C at 760 mmHg
• Flash Point: 125.9°C
• Density: 1.07g/cm³
• Vapor Pressure: 4.73E-05mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 1-cyclohexyl-3-(4-methylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexyl-3-(4-methylphenyl)urea(89609-46-1)
• EPA Substance Registry System: 1-cyclohexyl-3-(4-methylphenyl)urea(89609-46-1)

Safety Data

• Hazardous Substances Data: 89609-46-1(Hazardous Substances Data)

Usage

Chemical class

Urea derivatives

Composition

Cyclohexyl group and 4-methylphenyl group connected to a urea functional group

Industrial applications

Production of pharmaceuticals, agrochemicals, and dyes

Biological activities

Potential anti-cancer and anti-inflammatory properties

Synthesis utility

Used as a building block in the synthesis of other organic compounds due to unique structural features and reactivity

Diverse uses

Potential applications in various fields

Upstream product

• 106-49-0 p-toluidine 
• 3173-53-3 Cyclohexyl isocyanate 
• 931-53-3 Cyclohexyl isocyanide 
• 108-91-8 cyclohexylamine 
• 59046-28-5 p-toluoyl-1H-1,2,3-benzotriazole 
• 86065-10-3 O-allyl-N-(4-methylphenyl)carbamate 
• 37934-96-6 2,2,2-trichloroethyl N-p-tolylcarbamate 
• 33275-26-2 N-(4-methylphenyl)-O-phenyl carbamate 
• 622-58-2 p-Tolylisocyanate 

Downstream Products

• 89609-48-3 N¹-Cyclohexyl-3--N²-(p-tolyl)propiolamidin 
• 89609-63-2 2-Cyclohexylamino-6-methyl-4-chinolin 
• 89609-45-0 N-cyclohexyl-N'-(p-tolyl)methanediimine 

Relevant articles and documents

An Improved Synthesis of Urea Derivatives from N -Acylbenzotriazole via Curtius Rearrangement

The good leaving tendency of the benzotriazole moiety has been exploited for the synthesis of symmetric, unsymmetric, N -acyl, and cyclic ureas in good yields from N -acylbenzotriazoles by treating the latter with various amines in the presence of TMSN 3 /Et 3 N in a sealed tube. The salient features of the devised protocol includes the high-yield, mild, metal-free, one-pot reaction conditions, and short reaction time. Furthermore, in many cases, no column chromatography is required for the purification.

Novel Direct Synthesis of Asymmetrical Urea Compounds from Trichloroethyl Carbamates Using Catalytic DBU

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Cobalt(II)-catalyzed isocyanide insertion reaction with amines under ultrasonic conditions: A divergent synthesis of ureas, thioureas and azaheterocycles

Cobalt(II) acetylacetonate-catalyzed isocyanide insertion reactions with amines utilizing tert-butyl hydroperoxide (TBHP) as an oxidant under ultrasound conditions have been developed, which lead to the synthesis of ureas, thioureas, as well as 2-aminoben