896104-91-9

Basic information

• Product Name: Carbonic acid (2Z,11E)-(5S,6R,9S,10S,15S,16S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-isopropyl-9,12,16-trimethyl-tricyclo[13.3.0.0^5,9]octadeca-1⁽¹⁸⁾,2,11-trien-10-yl ester methyl ester
• Synonyms: Carbonic acid (2Z,11E)-(5S,6R,9S,10S,15S,16S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-isopropyl-9,12,16-trimethyl-tricyclo[13.3.0.0^5,9]octadeca-1⁽¹⁸⁾,2,11-trien-10-yl ester methyl ester
• CAS NO: 896104-91-9
• Molecular Weight: 669.033
• Mol File: 896104-91-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbonic acid (2Z,11E)-(5S,6R,9S,10S,15S,16S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-isopropyl-9,12,16-trimethyl-tricyclo[13.3.0.0^5,9]octadeca-1⁽¹⁸⁾,2,11-trien-10-yl ester methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonic acid (2Z,11E)-(5S,6R,9S,10S,15S,16S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-isopropyl-9,12,16-trimethyl-tricyclo[13.3.0.0^5,9]octadeca-1⁽¹⁸⁾,2,11-trien-10-yl ester methyl ester(896104-91-9)
• EPA Substance Registry System: Carbonic acid (2Z,11E)-(5S,6R,9S,10S,15S,16S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-6-isopropyl-9,12,16-trimethyl-tricyclo[13.3.0.0^5,9]octadeca-1⁽¹⁸⁾,2,11-trien-10-yl ester methyl ester(896104-91-9)

Safety Data

• Hazardous Substances Data: 896104-91-9(Hazardous Substances Data)

Upstream product

• 896104-56-6 1-(3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propoxymethyl)-4-methoxy-benzene 
• 896104-57-7 3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propan-1-ol 
• 896104-59-9 C₄₆H₇₀O₂Si₂ 
• 896104-58-8 3-{(1S,5S)-2-[(Z)-3-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-1-(tert-butyl-diphenyl-silanyloxymethyl)-propenyl]-5-methyl-cyclopent-2-enyl}-propionaldehyde 
• 896104-61-3 ((1S,2S,3R)-2-{(Z)-4-(tert-Butyl-diphenyl-silanyloxy)-3-[(4S,5S)-5-((E)-4-iodo-3-methyl-but-3-enyl)-4-methyl-cyclopent-1-enyl]-but-2-enyl}-3-isopropyl-1-methyl-cyclopentyl)-methanol 
• 896104-62-4 (1S,2S,3R)-2-{(Z)-4-(tert-Butyl-diphenyl-silanyloxy)-3-[(4S,5S)-5-((E)-4-iodo-3-methyl-but-3-enyl)-4-methyl-cyclopent-1-enyl]-but-2-enyl}-3-isopropyl-1-methyl-cyclopentanecarbaldehyde 
• 896104-77-1 (Z)-4-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-2-{(4S,5S)-5-[3-(4-methoxy-benzyloxy)-propyl]-4-methyl-cyclopent-1-enyl}-but-2-en-1-ol 
• 896104-55-5 (Z)-4-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-2-{(4S,5S)-5-[3-(4-methoxy-benzyloxy)-propyl]-4-methyl-cyclopent-1-enyl}-but-2-enoic acid methyl ester 
• 896104-60-2 {(1S,2S,3R)-2-[(Z)-4-(tert-Butyl-diphenyl-silanyloxy)-3-((4S,5S)-5-but-3-ynyl-4-methyl-cyclopent-1-enyl)-but-2-enyl]-3-isopropyl-1-methyl-cyclopentyl}-methanol 
• 896104-54-4 Trifluoro-methanesulfonic acid (4S,5S)-5-[3-(4-methoxy-benzyloxy)-propyl]-4-methyl-cyclopent-1-enyl ester 
• 896104-48-6 4-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-but-2-ynoic acid methyl ester 
• 896104-52-2 (E)-(4S,5S)-4-[3-(4-Methoxy-benzyloxy)-propyl]-5-methyl-octa-1,6-dien-3-one 
• 896104-72-6 2-[(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-isopropyl-2-methyl-cyclopentyl]-ethanol 
• 896104-47-5 tert-Butyl-((1S,2S,3R)-3-isopropyl-1-methyl-2-prop-2-ynyl-cyclopentylmethoxy)-dimethyl-silane 

Relevant articles and documents

A synthetic approach toward nitiol: Construction of two 1,22-dihydroxynitianes

Synthetic work toward the total synthesis of nitiol has culminated in the construction of two epimeric hydroxylated derivatives, the 1,22- dihydroxynitianes. Key stereodefining steps in the construction of the A-ring fragment (13) were the use of a siloxy-epoxide rearrangement reaction, a Pauson-Khand reaction, a Norrish 1 photochemical cleavage reaction, and a highly regio- and stereoselective hydrostannylation reaction of an ynoate. The stereochemistry of the synthetically challenging C-ring fragment (20) was established using an Ireland-Claisen reaction and a Grubbs ring-closing metathesis process as key steps. The 12-membered B-ring of the nitiane skeleton was constructed using a copper-promoted Stille cross-coupling and a Kishi-Hiyama-Nozaki carbonyl addition reaction. Unfortunately, the carbonyl addition reaction produced hydroxyl functionality that could not be selectively removed. Consequently, a synthesis of epimeric 1,22-dihydroxynitianes, which are compounds that are structural hybrids of two natural products, nitiol and variculanol, was completed.