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Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-chloropyridin-2-yl)propan-1-one is utilized as a key intermediate in the development of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs. Its presence in drug molecules can impart specific therapeutic properties, making it valuable in the creation of new medications.
Used in Agrochemical Development:
In the agrochemical industry, 1-(4-chloropyridin-2-yl)propan-1-one serves as a building block for the synthesis of compounds with pesticidal or herbicidal properties. Its chemical structure allows for the design of molecules that can effectively control, repel, or kill unwanted organisms in agricultural settings.
Used in Medicinal Chemistry Research:
1-(4-chloropyridin-2-yl)propan-1-one is employed as a research tool in medicinal chemistry to explore its potential in the formation of bioactive molecules. Its unique structure provides a platform for studying structure-activity relationships and optimizing the pharmacological profiles of new chemical entities.
Used in Materials Science:
Within the field of materials science, 1-(4-chloropyridin-2-yl)propan-1-one is used to develop new organic materials with specific properties. Its versatility in chemical reactions enables the creation of materials with tailored characteristics for various applications, such as in sensors, catalysts, or advanced materials for energy storage and conversion.

Upstream product

• 1121-76-2 4-chloropyridine N-oxide 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 
• 925-90-6 ethylmagnesium bromide 

Relevant academic research and scientific papers

Engineering an iridium-containing metal-organic molecular capsule for induced-fit geometrical conversion and dual catalysis

By introducing photoactive fac-tris(2-phenylpyridine)iridium moieties as a ligand backbone to constrain the coordination geometry of cobalt ions, a multifunctional Ir2Co3-type capsule was achieved and showed induced-fit capsule-capsule conversion by cooperative binding one carbonate anion with the equatorial Co(ii) centers. The capsule combined photocatalysis and transition metal activation synergistically and exhibited efficient catalytic ability on visible light-activated α-trichloromethylation.

Enantioselective, catalytic trichloromethylation through visible-light-activated photoredox catalysis with a chiral iridium complex

An enantioselective, catalytic trichloromethylation of 2-acyl imidazoles and 2-acylpyridines is reported. Several products are formed with enantiomeric excess of ≥99%. In this system, a chiral iridium complex serves a dual function, as a catalytically active chiral Lewis acid and simultaneously as a precursor for an in situ assembled visible-light-triggered photoredox catalyst.

Biocatalytic preparation of optically active 4-(N,N-dimethylamino)pyridines for application in chemical asymmetric catalysis

4-Chloro-2-(1-hydroxybenzyl)pyridine and 4-chloro-2-(1-hydroxyalkyl)pyridines were obtained with moderate to excellent enantiomeric excesses and high isolated yields by bioreduction with Baker's yeast of the corresponding ketones. The resulting optically active alcohols were transformed into adequate DMAP derivatives, which have been applied in asymmetric catalytic processes as nucleophilic catalysts in the stereoselective chemical alkoxycarbonylation of 1-phenylethanol or as chiral ligands in the enantioselective addition of diethylzinc to benzaldehyde.

Chemoenzymatic synthesis of chiral 4-(N,N-dimethylamino)pyridine derivatives

Chiral 4-(N,N-dimethylamino)pyridine derivatives have been prepared through a chemoenzymatic synthesis where the enzymatic kinetic resolution of a family of 4-chloro-2-(1-hydroxyalkyl)pyridines is the key step for the formation of potentially important chiral catalysts. Pseudomonas cepacia lipase (PSL) showed excellent enantioselectivity in the acylation of the (R)-enantiomers (E > 200) using vinyl acetate as acylating agent and THF as solvent, obtaining products and substrates enantiomerically pure and with excellent yields.