89625-16-1

Basic information

• Product Name: 2-Pentanone, 3-(diphenylphosphinyl)-5-hydroxy-
• CAS NO: 89625-16-1
• Molecular Formula: C17H19O3P
• Molecular Weight: 302.31
• Mol File: 89625-16-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pentanone, 3-(diphenylphosphinyl)-5-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pentanone, 3-(diphenylphosphinyl)-5-hydroxy-(89625-16-1)
• EPA Substance Registry System: 2-Pentanone, 3-(diphenylphosphinyl)-5-hydroxy-(89625-16-1)

Safety Data

• Hazardous Substances Data: 89625-16-1(Hazardous Substances Data)

Upstream product

• 889-57-6 3-(diphenylphosphinoyl)-1-propanol 
• 2129-89-7 diphenyl(methyl)phosphine oxide 
• 101680-86-8 (4-diphenylphosphinoyl)-2-butanol 
• 14580-99-5 3-diphenylphosphinoylpropyl acetate 

Downstream Products

• 764-37-4 (E)-3-penten-1-ol 
• 146964-57-0 5-(tert-Butyl-diphenyl-silanyloxy)-3-(diphenyl-phosphinoyl)-pentan-2-ol 
• 89625-19-4 erythro-3-diphenylphosphinoylpentane-1,4-diol 
• 89625-19-4 threo-3-diphenylphosphinoylpentane-1,4-diol 
• 1071-73-4 5-Hydroxy-2-pentanone 
• 765-43-5 Cyclopropyl methyl ketone 

Relevant articles and documents

ACYL TRANSFER REACTIONS WITH PHOSPHINE OXIDES: SYNTHESIS OF E-HOMOALLYLIC ALCOHOLS, CYCLOPROPYL KETONES, AND γ-HYDROXY KETONES

Esters of 3-hydroxypropylphosphine oxides rearrange in base by O to C acyl (RCO) transfer to give the hydroxy ketones (8). threo-Selective reduction of (8) leads to pure E-homoallylic alcohols whilst C to O acyl )Ph2PO) transfer leads to γ-hydroxy ketones with nucleophilic aqueous base or cyclopropyl ketones with BuOKt - HOBut.

SYNTHESIS OF SINGLE ISOMERS (E OR Z) OF UNSATURATED ALCOHOLS BY THE HORNER-WITTIG REACTION

Single isomers (E or Z) of homoallylic and higher alcohols can be synthesised from ω-hydroxyalkyldiphenylphosphine oxides and aldehydes, or from alkyldiphenylphosphine oxides and lactones