89625-49-0

Upstream product

• 89625-39-8 (2S,4R)-N-(benzyloxycarbonyl)-4-acetoxyproline 

Downstream Products

• 129679-72-7 C₁₅H₁₇NO₅ 
• 89625-52-5 Acetic acid (S)-1-[2-benzoylamino-5-methoxy-4-(toluene-4-sulfonyloxy)-benzoyl]-5-(tetrahydro-pyran-2-yloxymethyl)-pyrrolidin-3-yl ester 
• 89625-54-7 Acetic acid (S)-1-[2-benzoylamino-5-methoxy-4-(toluene-4-sulfonyloxy)-benzoyl]-5-methanesulfonyloxymethyl-pyrrolidin-3-yl ester 
• 89625-55-8 Acetic acid (S)-1-[2-benzoylamino-5-methoxy-4-(toluene-4-sulfonyloxy)-benzoyl]-5-bromomethyl-pyrrolidin-3-yl ester 
• 89625-53-6 Acetic acid (S)-1-[2-benzoylamino-5-methoxy-4-(toluene-4-sulfonyloxy)-benzoyl]-5-hydroxymethyl-pyrrolidin-3-yl ester 
• 89625-45-6 Acetic acid (S)-10-benzoyl-7-methoxy-5-oxo-8-(toluene-4-sulfonyloxy)-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl ester 
• 89625-56-9 Acetic acid 1-[2-benzoylamino-5-methoxy-4-(toluene-4-sulfonyloxy)-benzoyl]-5-methylene-pyrrolidin-3-yl ester 
• 89625-57-0 Toluene-4-sulfonic acid (S)-10-benzoyl-2-hydroxy-7-methoxy-5-oxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 89625-58-1 Toluene-4-sulfonic acid (S)-10-benzoyl-7-methoxy-2,5-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 89625-59-2 Toluene-4-sulfonic acid (S)-2-eth-(Z)-ylidene-7-methoxy-5-oxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-8-yl ester 
• 67731-61-7 sen-215 

Relevant academic research and scientific papers

Aminal-pyrrolidine organocatalysts - Highly efficient and modular catalysts for α-functionalization of carbonyl compounds

The substitution of the 4-position of hydroxyproline by a phenol group, together with an aminal on the 2-position, gave a synergistic effect leading to two powerful complementary organocatalysts. They show excellent enantiocontrol in the α-functionalization of a wide range of linear/ branched aldehydes and ketones, including Michael additions to ethenediyl disulfones or nitrostyrene and α-amination. We obtained ees up to 98.5 % with low catalyst loadings (down to 1 mol-%). As a proof of efficiency, TOFs of up to 1000 h-1 could be obtained.