89629-90-3

Upstream product

• 34662-36-7 3-chloro-5-nitrobenzoic acid 

Downstream Products

• 1332259-63-8 C₂₉H₁₅BrClN₅O₄S₂ 
• 145235-71-8 2-imino-3-(3-chloro-5-nitrobenzoylmethyl)thiazoline hydrobromide 
• 145235-75-2 6-(3-chloro-5-nitrophenyl)-2,3,5,6-tetrahydroimidazo<2,1-b>bthiazole 
• 145235-66-1 6-(3-amino-5-chlorophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride 
• 145028-61-1 4-Chloro-N-[3-chloro-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-benzamide 
• 145028-81-5 3-[2-Chloro-2-(3-chloro-5-nitro-phenyl)-ethyl]-thiazolidin-2-ylideneamine 

Relevant academic research and scientific papers

HETEROCYCLIC DERIVATIVES AND USE THEREOF

A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated

Synthesis and anti-filarial activity of 6-(3-aminophenyl)-2,3,5,6-tetrahydroimidazothiazole derivatives

Structure-activity studies against filariae are described for a series of derivatives of 6-(3-aminophenyl)-2,3,5,6-tetrahydroimidazothiazole (15) derivatives.In an in vivo assay using gerbils implanted with both Acanthocheilonema viteae and Brugia pahangi, the former parasite was shown to be the more sensitive to a range of amides of 15.None of these compounds, however, had any activity at 5*10(-5) mol against the worms in vitro suggesting that they required in vivo activation.This was confirmed when the benzamido derivative (6) was shown to be rapidlymetabolised in gerbils to the parent amine (15).The latter had potent effects on filariae both in vivo and in in vitro but was also found to be toxic to mammals and unsuitable for further development.Unsuccessful attempts to improve upon the therapeutic index of 15 through the synthesis of various novel analogues are described. antifilarial / 6-(3-aminophenyl)-2,3,5,6-tetrahydroimidazothiazole / A viteae / B pahangi / filaricide