89635-06-3Relevant academic research and scientific papers
Novel antifungal polyene amides from the myxobacterium Cystobacter fuscus: Isolation, antifungal activity and absolute structure determination
Kundim, Bangi A.,Itou, Yu,Sakagami, Youji,Fudou, Ryosuke,Yamanaka, Shigeru,Ojika, Makoto
, p. 10217 - 10221 (2004)
Three new unstable metabolites, (6E,10Z)-2′-O-methylmyxalamide D (1), 2′-O-methylmyxalamide D (2) and (6E)-2′-O-methylmyxalamide D (3) were isolated from the myxobacterium Cystobacter fuscus. The planar structures were elucidated by spectroscopic analyses to be geometrical isomers of a polyene amide related to a myxobacterial metabolite, myxalamide D (4). Their absolute stereochemistry was determined by synthesis of degradation products. Antifungal activities of 1-3 as well as their acetates were evaluated against the phythopathogenic fungus Phythopthora capsici. Three new polyene antibiotics 1-3, structurally related to myxalamide D, were isolated as unstable geometrical isomers. The absolute stereochemistry was elucidated by synthesis of degradation products.
