896506-33-5Relevant academic research and scientific papers
Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations
Niida, Ayumu,Mizumoto, Makiko,Narumi, Tetsuo,Inokuchi, Eriko,Oishi, Shinya,Ohno, Hiroaki,Otaka, Akira,Kitaura, Kazuo,Fujii, Nobutaka
, p. 4118 - 4129 (2007/10/03)
We have carefully examined the organocopper-mediated reduction-alkylation of γ-acetoxy or γ,γ-difluoro-α,β-unsaturated- δ-lactams for the synthesis of (Z)-alkene- or (E)-fluoroalkene-containing diketopiperazine mimetics. Reduction of acetates 2, 12, 14, a
