89660-11-7Relevant academic research and scientific papers
Cobalt-Catalyzed Regioselective Ortho C(sp2)-H Bond Nitration of Aromatics through Proton-Coupled Electron Transfer Assistance
Nageswar Rao, Desaboini,Rasheed, Sk.,Raina, Gaurav,Ahmed, Qazi Naveed,Jaladanki, Chaitanya Kumar,Bharatam, Prasad V.,Das, Parthasarathi
, p. 7234 - 7244 (2017/07/26)
A cobalt-catalyzed proton-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp2)-H bonds using chelation-assisted removable vicinal diamine directing groups was developed. The reaction proceeded under mild conditions in the presence of Co(OAc)2·4H2O as the catalyst with AgNO2 utilized as the nitro source as well as terminal oxidant in the presence of O2 as an external oxidant. No external base or additives were required for this process. Controlled experiments and mechanistic investigations with DFT calculations revealed that the reaction proceeds through a PCET promoted nitro functional group transfer pathway. Moreover, the produced compounds are valuable and pharmaceutically quite relevant.
RECEPTOR FUNCTION REGULATING AGENT
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Page/Page column 82-83, (2010/11/28)
The present invention relates to a GPR40 receptor function regulator comprising a fused imidazole compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. The GPR40 receptor funct
The Preparation of All the Monochloro-α-carbolines and the Assignment of the 13C N.M.R. Spectrum of α-Carboline
Mohamed, Murtedsa bin,Parrick, John
, p. 577 - 593 (2007/10/02)
The five previously unknown chloro-α-carbolines are prepared, the 1H n.m.r. spectra of the chloro-α-carbolines are described, and the 13C n.m.r. spectrum of α-carboline is assigned.
