89664-20-0

Basic information

• Product Name: NOMIFENSINE
• Synonyms: NOMIFENSINE;(+)-Nomiphensine;(R)-1,2,3,4-Tetrahydro-2-methyl-4-phenyl-8-isoquinolinamine;8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (R)-;Brn 6064059;(R)-nomifensine
• CAS NO: 89664-20-0
• Molecular Formula: C₁₆H₁₈N₂
• Molecular Weight: 238.33
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals
• Mol File: 89664-20-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NOMIFENSINE(CAS DataBase Reference)
• NIST Chemistry Reference: NOMIFENSINE(89664-20-0)
• EPA Substance Registry System: NOMIFENSINE(89664-20-0)

Safety Data

• Hazardous Substances Data: 89664-20-0(Hazardous Substances Data)

Usage

Description

NOMIFENSINE is a novel R-enantiomer antidepressant with a unique bicyclic structure, which distinguishes it from existing tricyclic and tetracyclic antidepressants. It is a pale yellow solid and has gained attention for its potential use in the treatment of depression.

Uses

Used in Pharmaceutical Industry:
NOMIFENSINE is used as an antidepressant medication for the treatment of depression. Its unique bicyclic structure allows it to act differently from traditional tricyclic and tetracyclic antidepressants, offering a new option for patients who may not respond well to other treatments.
Additionally, due to its distinct chemical properties, NOMIFENSINE may also be utilized in research and development for the discovery of new drugs with improved efficacy and reduced side effects in the treatment of mood disorders.

Upstream product

• 1904-69-4 2-amino-N-methylbenzylamine 
• 66486-62-2 (2-amino-benzylidene)-methyl-amine 
• 529-23-7 o-aminobenzaldehyde 
• 24526-64-5 nomifensine 
• 65514-97-8 N-(2-Aminobenzyl)-2-(methylamino)-1-phenyl-1-ethanol 
• 119810-30-9 2-[(2-Amino-benzyl)-methyl-amino]-1-phenyl-ethanone 

Downstream Products

• 118411-56-6 (R)-(-)-2-Methyl-4-phenyl-8-ethoxycarbonylamino-1,2,3,4-tetrahydroisochinolin 

Relevant articles and documents

SYNTHESIS OF THERAPEUTIC AND DIAGNOSTIC DRUGS CENTERED ON REGIOSELECTIVE AND STEREOSELECTIVE RING OPENING OF AZIRIDINIUM IONS

Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.

Resolution, Absolute Stereochemistry, and Enantioselective Activity of Nomifensine and Hexahydro-1H-indenopyridines

Nomifensine and three selected compounds from the series of H4a,H5-trans,H4a,H9b-cis-2,3,4,4a,5,9b-hexahydro-1H-indenopyridines have been resolved into their enantiomers.All compounds exhibit pronounced enantioselective activity with respect to their inhibition of tetrabenazine-induced ptosis and potentiation of yohimbine toxicity.Nomifensine exhibits the same preference for one enantiomer with respect to dopamine and norepinephrine reuptake, whereas in the indenopyridine series in vitro experiments do not discriminate between the optical antipodes.The absolute stereochemistry of the pharmacologically active enantiomers in both series was determined by X-ray analyses and comparative CD spectra.For biological activity the diphenylmethane is an essential structure feature in both series.Its absolute configuration proved to be 4S for nomifensine and 5S for indenopyridines.The similar pharmacological profile of the two chemical entities is therefor reflected in an identical configuration of this pharmacologically important molecular part.