89665-56-5Relevant academic research and scientific papers
On the pharmaceutical and biopharmaceutical evaluation of acetylaminonitropropoxybenzene (falimint). Part IV. Biotransformation of the active agent
Gerlach,Buge,Peinhardt,Furst
, p. 42 - 45 (2007/10/02)
2-Acetamino-4-nitropropoxybenzene is metabolized almost completely. Till now in urine of man seven components have been detected. The main way of metabolism is the oxidation of propoxy group of a carboxyl group. Also the deacetylated compound of this acid has been found to a certain extent. A further metabolite is supposed to be oxidized in the side chain in another way. In a higher extent dealkylation to 2-acetamino-4-nitrophenol takes place which is eliminated probably in conjugation with glucuronic acid. Free 2-acetamino-4-nitrophenol and 2-amino-4-nitrophenol respectively are only detectable in traces. Deacetylation of 2-amino-4-nitropropoxybenzene takes place only in a very small extent. Till now metabolites with reduced nitro group haven't been found.
