896719-54-3 Usage
Description
3',5'-Di-O-tert-butyldiMethylsilyl-2'-deoxy-8-[(3-Methyl-8-Methyl-3H-iMidazo[4,5-f]quinoxalin-2-yl)aMino]-6-O-benzyl-guanosine is a complex organic compound with a unique chemical structure. It is characterized by its 2'-deoxyguanosine core, which is modified with various functional groups, including a 3',5'-di-O-tert-butyldiMethylsilyl moiety, a 6-O-benzyl group, and an 8-[(3-Methyl-8-Methyl-3H-iMidazo[4,5-f]quinoxalin-2-yl)aMino] substituent. 3',5'-Di-O-tert-butyldiMethylsilyl-2'-deoxy-8-[(3-Methyl-8-Methyl-3H-iMidazo[4,5-f]quinoxalin-2-yl)aMino]-6-O-benzyl-guanosine is of interest in the field of chemistry and biochemistry due to its potential applications in various areas.
Uses
Used in the Preparation of 2'-Deoxyguanosine-C8 Adducts:
3',5'-Di-O-tert-butyldiMethylsilyl-2'-deoxy-8-[(3-Methyl-8-Methyl-3H-iMidazo[4,5-f]quinoxalin-2-yl)aMino]-6-O-benzyl-guanosine is used as a key intermediate in the synthesis of 2'-Deoxyguanosine-C8 adducts. These adducts are important in various applications, such as in the development of new drugs, the study of chemical reactions involving nucleic acids, and the investigation of the interactions between DNA and other molecules.
In the pharmaceutical industry, 2'-Deoxyguanosine-C8 adducts can be used as potential therapeutic agents, targeting specific enzymes or proteins involved in disease processes. They may also be employed as molecular probes to study the mechanisms of DNA damage and repair, providing valuable insights into the development of novel cancer therapies and other treatments.
In the field of biochemistry, 3',5'-Di-O-tert-butyldiMethylsilyl-2'-deoxy-8-[(3-Methyl-8-Methyl-3H-iMidazo[4,5-f]quinoxalin-2-yl)aMino]-6-O-benzyl-guanosine can be utilized to investigate the interactions between DNA and various chemical agents, such as carcinogens or chemotherapeutic drugs. This can help researchers understand the molecular basis of DNA damage and the development of resistance to certain treatments.
Overall, 3',5'-Di-O-tert-butyldiMethylsilyl-2'-deoxy-8-[(3-Methyl-8-Methyl-3H-iMidazo[4,5-f]quinoxalin-2-yl)aMino]-6-O-benzyl-guanosine is a versatile compound with potential applications in various industries, including pharmaceuticals, biochemistry, and drug development. Its unique structure and properties make it a valuable tool for researchers and scientists working in these fields.
Check Digit Verification of cas no
The CAS Registry Mumber 896719-54-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,6,7,1 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 896719-54:
(8*8)+(7*9)+(6*6)+(5*7)+(4*1)+(3*9)+(2*5)+(1*4)=243
243 % 10 = 3
So 896719-54-3 is a valid CAS Registry Number.
896719-54-3Relevant articles and documents
Chemical synthesis of 2′-deoxyguanosine-C8 adducts with heterocyclic amines: An application to synthesis of oligonucleotides site-specifically adducted with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
Takamura-Enya, Takeji,Ishikawa, Satoko,Mochizuki, Masataka,Wakabayashi, Keiji
, p. 770 - 778 (2007/10/03)
Synthesis of 2′-deoxyguanosine-C8 adducts (dG-C8 adducts) with mutagenic/carcinogenic heterocyclic amines (HCAs) was achieved via the Buchwald-Hartwig arylamination reaction. By using tris-(dibenzylideneacetone) dipalladium (Pd2dba3)
