896728-21-5Relevant articles and documents
Kinesin spindle protein (KSP) inhibitors. Part 4:1 Structure-based design of 5-alkylamino-3,5-diaryl-4,5-dihydropyrazoles as potent, water-soluble inhibitors of the mitotic kinesin KSP
Cox, Christopher D.,Torrent, Maricel,Breslin, Michael J.,Mariano, Brenda J.,Whitman, David B.,Coleman, Paul J.,Buser, Carolyn A.,Walsh, Eileen S.,Hamilton, Kelly,Schaber, Michael D.,Lobell, Robert B.,Tao, Weikang,South, Vicki J.,Kohl, Nancy E.,Yan, Youwei,Kuo, Lawrence C.,Prueksaritanont, Thomayant,Slaughter, Donald E.,Li, Chunze,Mahan, Elizabeth,Lu, Bing,Hartman, George D.
, p. 3175 - 3179 (2006)
Molecular modeling in combination with X-ray crystallographic information was employed to identify a region of the kinesin spindle protein (KSP) binding site not fully utilized by our first generation inhibitors. We discovered that by appending a propylam