896933-66-7Relevant articles and documents
First dual M3 antagonists-PDE4 inhibitors: Synthesis and SAR of 4,6-diaminopyrimidine derivatives
Provins, Laurent,Christophe, Bernard,Danhaive, Pierre,Dulieu, Jacques,Durieu, Véronique,Gillard, Michel,Lebon, Florence,Lengelé, Sébastien,Quéré, Luc,Van Keulen, Berendjan
, p. 1834 - 1839 (2006)
SAR around 4,6-diaminopyrimidine derivatives allowed the discovery of the first potent dual M3 antagonists and PDE4 inhibitors. Various chemical modulations around that scaffold led to the discovery of ucb-101333-3 which is characterized by the