89694-44-0

Usage

Uses

Used in Organic Synthesis:
2-BROMO-5-METHOXYPHENYLBORONIC ACID is used as a building block in organic synthesis for the preparation of various biologically active compounds. Its unique structure allows for the formation of carbon-carbon bonds through cross-coupling reactions, facilitating the creation of complex organic molecules.
Used in Medicinal Chemistry:
In the pharmaceutical industry, 2-BROMO-5-METHOXYPHENYLBORONIC ACID is utilized as a key intermediate in the synthesis of pharmaceutical compounds. Its ability to form carbon-carbon bonds makes it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-BROMO-5-METHOXYPHENYLBORONIC ACID also finds applications in the agrochemical industry, where it is employed in the synthesis of agrochemicals such as pesticides and herbicides. Its reactivity and functional groups contribute to the development of effective and targeted agrochemical products.

InChI:InChI=1/C7H8BBrO3/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,10-11H,1H3

Upstream product

• 10365-98-7 3-methoxyphenylboronic acid 

Downstream Products

• 867332-71-6 C₁₅H₁₃BrN₄O 
• 934542-98-0 3-(2-bromo-5-methoxyphenyl)-2-fluoro-5-methyl-pyridine 
• 1445376-70-4 4-(2-bromo-5-methoxyphenyl)-6-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-amine 
• 1256781-58-4 2-(2-bromo-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

METHOD FOR PRODUCING PHENOTHIAZINE DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing a phenothiazine derivative that has reduced limitations on the number of functional groups that can be arranged to it, prevents the occurrence of by-products, and secures high yields. SOLUTION: A method for producing a phenothiazine derivative includes the step of reacting a benzyne precursor with a compound represented by formula (A) (RA1-RA5 independently represent H, a hydroxy group or an organic group, RA1 and RA2, RA2 and RA3, RA3 and RA4 may together form, with an adjacent atom, a 5-8 membered ring; RA6 is H or an optionally substituted C1-C20 hydrocarbon group; X is a halogen atom). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

A practical lewis base catalyzed electrophilic chlorination of arenes and heterocycles

A mild phosphine sulfide catalyzed electrophilic halogenation of arenes and heterocycles that utilizes inexpensive and readily available N-halosuccinimides is disclosed. This methodology is shown to efficiently chlorinate diverse aromatics, including simple arenes such as anthracene, and heterocycles such as indoles, pyrrolopyrimidines, and imidazoles. Arenes with Lewis acidic moieties also proved amenable, underscoring the mild nature of this chemistry. Lewis base catalysis was also found to improve several diverse aromatic brominations and iodinations.

Mild silver(I)-mediated regioselective iodination and bromination of arylboronic acids

A convenient and regioselective silver(I)-mediated electrophilic iodination and bromination reaction of arylboronic acids has been developed. The boronic acid does not require protection prior to the reaction, which can be performed on a multigram scale with moderate to excellent yields. A mild, simple, and effective method is disclosed to provide ortho-haloarylboronic acids that can be used as useful intermediates in selective sequential Suzuki-Miyaura cross-coupling reactions to provide ortho-triaryl derivatives in good yields.