897050-95-2

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 218632-01-0 3-fluoro-4-nitrobenzonitrile 
• 897050-94-1 3-(2-bromophenoxy)-4-nitrobenzonitrile 

Downstream Products

• 897050-96-3 4-[2-(2-bromophenoxy)-4-cyanophenylamino]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Microwave assisted rapid synthesis of phenoxazines and benzopyridoxazines

A facile protocol for the synthesis of phenoxazines and benzopyridoxazines by Smiles rearrangement have been demonstrated in short reaction time under microwave irradiation. The control experiments suggest that a reaction proceeds through Smiles rearrangement followed SNAr ring closure by in situ cascade process. In our present work, both the electron donating and electron withdrawing groups were tolerant and provided a corresponding phenoxazine/benzopyridoxazine in good to moderate yields.

Tricyclic delta-opioid modulators

The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using com