89706-87-6Relevant articles and documents
Cyclic amidino agents useful as nitric oxide synthase inhibitors
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, (2008/06/13)
The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.
2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase
Hagen, Timothy J.,Bergmanis, Arija A.,Kramer, Steven W.,Fok, Kam F.,Schmelzer, Albert E.,Pitzele, Barnett S.,Swenton, Lydia,Jerome, Gina M.,Kornmeier, Christine M.,Moore, William M.,Branson, Linda F.,Connor, Jane R.,Manning, Pamela T.,Currie, Mark G.,Hallinan, E. Ann
, p. 3675 - 3683 (2007/10/03)
A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase (hiNOS) isoform versus the human endothelial nitric oxide synthase (heNOS) and the human neuronal ni
