89723-40-0Relevant academic research and scientific papers
A convenient method for converting hydroxyacetophenones into their ethylene or trimethylene acetals
Ono, Fumiaki,Takenaka, Hirotaka,Fujikawa, Toshikazu,Mori, Masaki,Sato, Tsuneo
, p. 1318 - 1322 (2009)
Various types of hydroxyacetophenones are efficiently converted into the corresponding ethylene acetals in the presence of ethane-1,2-diol, triisopropyl orthoformate, and a catalytic amount of cerium(III) trifluoromethanesulfonate under mild reaction conditions. The homologous trimethylene acetals can be also prepared in the same way. Georg Thieme Verlag Stuttgart.
Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)
Schwarz, Theresa,Montanari, Floriane,Cseke, Anna,Wlcek, Katrin,Visvader, Lene,Palme, Sarah,Chiba, Peter,Kuchler, Karl,Urban, Ernst,Ecker, Gerhard F.
, p. 1380 - 1394 (2016/08/28)
The transmembrane ABC transporters P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are widely recognized for their role in cancer multidrug resistance and absorption and distribution of compounds. Furthermore, they are linked to drug–drug interactions and toxicity. Nevertheless, due to their polyspecificity, a molecular understanding of the ligand-transporter interaction, which allows designing of both selective and dual inhibitors, is still in its infancy. This study comprises a combined approach of synthesis, in silico prediction, and in vitro testing to identify molecular features triggering transporter selectivity. Synthesis and testing of a series of 15 propafenone analogues with varied rigidity and basicity of substituents provide first trends for selective and dual inhibitors. Results indicate that both the flexibility of the substituent at the nitrogen atom, as well as the basicity of the nitrogen atom, trigger transporter selectivity. Furthermore, inhibitory activity of compounds at P-gp seems to be much more influenced by logP than those at BCRP. Exploiting these differences further should thus allow designing specific inhibitors for these two polyspecific ABC-transporters.
A green procedure for the protection of carbonyl compounds catalyzed by iodine in ionic liquid
Ren, Yi-Ming,Cai, Chun
body text, p. 7110 - 7112 (2015/04/15)
Aldehydes and ketones are protected with ethylene glycol in the presence of a catalytic amount of iodine in PEG ionic liquid (IL 400) under mild conditions to afford the corresponding ketals in good yields. The recovery of iodine is facilitated by the ionic liquid. The recovered catalyst was reused six times with consistent activity.
